血管性抑郁症功能磁共振成像研究进展  

Research Development of Functional Magnetic Resonance Imaging on Vascular Depression

作　　者：谭赛[1,2] 黄世敬[1] 方继良[3] 

机构地区：[1]中国中医科学院广安门医院中药研发中心,北京102600 [2]中国中医科学院广安门医院南区,北京102600 [3]中国中医科学院广安门医院放射科,北京102600

出　　处：《世界科学技术-中医药现代化》2017年第8期1346-1350,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金面上项目(81573790):基于IncRNAmiRNA网络对神经血管单元稳态调控探讨益气开郁中药抗抑郁机制;负责人:黄世敬;北京市科技计划(Z161100001816013):开心解郁颗粒治疗血管性抑郁的成药性研究;负责人:黄世敬

摘　　要：旨在总结血管性抑郁症(Vascular Depression,VD)脑部功能磁共振成像的研究进展情况,包括弥散张量成像和血氧水平依赖功能磁共振成像。通过对VD患者脑组织及脑功能进行实时成像,发现与抑郁相关脑区的神经通路及脑功能活动发生变化。其中脑白质异常高信号是VD主要病理改变,边缘系统-皮层-纹状体-丘脑环路破坏是VD发病的重要环节。前额叶皮质、边缘皮质(如扣带回、海马回)、杏仁核、小脑等脑区的异常功能连接为VD功能影像学的主要表现。血管性抑郁发病机制复杂,功能磁共振成像作为一种非损伤性活体检测技术将对血管性抑郁的全面认识发挥重要作用,为VD的临床诊疗提供新的思路。The paper was aimed to summarize the development of vascular depression （VD） in functional magnetic resonance imaging （fMRI） of brain research, including diffusion tensor imaging and blood oxygenation level dependent- fMRI. Through the real-time imaging of brain tissues and brain function in VD patients, it was found that the neurological and brain function in the brain regions related to depression were changed. The main pathologic changes were abnormal white matter hyperintensities of the brains. The key link of VD pathogenesis was that limbic system- cortex-striatum-thalamus circuits were destroyed. And the main performance of VD in fMRI was abnormal brain function connection in prefrontal cortex, limbic cortex （i.e., cingulate gyms, hippocampal gyms）, amygdala, cerebellum, and etc. in fMRI. The pathogenesis of VD was complex. As a noninvasive living brain function detection technique, fMRI will play an important role in the comprehensive understanding of VD and provide new ideas in clinical diagnosis and treatment.

关 键 词：血管性抑郁 弥散张量成像 血氧水平依赖功能磁共振成像 研究进展 

分 类 号：R965[医药卫生—药理学]