猴头菌提取物颗粒治疗小儿感染后脾虚综合征106例分析  

The Analysis of Hedgehog Fungus Extract Granules in the Treatment for Spleen Deficiency Syndrome after Infection in 106 Children

作　　者：李雪[1] 赵敏[1] 耿文婧 刘静[1] 苏华明[1] 

机构地区：[1]河北省石家庄市第一医院,河北石家庄050000

出　　处：《河北医学》2017年第10期1729-1732,共4页Hebei Medicine

基　　金：河北省卫生厅2013年医学科学研究重点课题;(编号:20130232);石家庄市科技局课题;(编号:141462843)

摘　　要：目的:探讨猴头菌提取物颗粒治疗小儿感染后脾虚综合征的临床疗效。方法:选取2016年1月至2016年12月106例小儿感染后脾虚综合征患者,根据随机数字法,将其分为对照组(双歧杆菌乳杆菌三联活菌片,48例)和观察组(对照组治疗基础上,给予猴头菌提取物颗粒,58例),比较两组治疗的总体疗效、治疗前后体液免疫及细胞免疫指标变化情况。结果:与对照组相比,观察组治疗的总有效率明显增高(96.6%vs70.8%,P<0.05),差异有统计学意义;与对照组相比,观察组明显改善患儿体液免疫功能,治疗后IgG、IgA水平均明显增高(P<0.05),差异有统计学意义;与对照组相比,观察组有效改善患儿细胞免疫功能,治疗后CD3、CD4、CD4/CD8水平均明显增高(P<0.05),差异有统计学意义。结论:猴头菌提取物颗粒能够明显改善感染后脾虚综合征患儿免疫功能,提高治疗的临床疗效。Objective： To study the clinical efficacy of hedgehog fungus extract granules in the treatment for spleen deficiency syndrome after infection in children. Methods： The 106 children patients with spleen deficiency syndrome after infection in our hospital during the period from Jan 2016 to Dec 2016 were randomized into the control group（ treatment of live combined Bifidobacterium and Lactobacillus tablets,48 patients） and the observation group（ addition to control group,treatment of hedgehog fungus extract granules,58 patients）according to the random number method. The total clinical efficacy,the changes of humoral immunity and cellular immunity pre-and post-treatment in two groups were compared. Results： Compared with the control group,the total effective rate of treatment was significantly increased in the observation group with statistical difference（ 96.6% vs 70.8%,P〈 0.05）; compared with the control group,the humoral immune function was obviously improved and the levels of Ig G and Ig A on post-treatment were significantly increased in the observation group with statistical difference（ P〈 0.05）; compared with the control group,the cellular immune function was obviously improved and the levels of CD3,CD4,CD4/CD8 on post-treatment were significantly increased in the observation group with statistical difference（ P 〈0.05）. Conclusion： The treatment of hedgehog fungus extract granules can significantly improve the immune function for spleen deficiency syndrome after infection in children and increase the clinical efficacy of treatment.

关 键 词：猴头菌提取物颗粒 小儿感染后脾虚综合征 免疫功能 

分 类 号：R272[医药卫生—中医儿科学]