Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3-deficient non-human primate  

作　　者：Jiezhao Zheng Zhujun Li Rui Tian Youming Lu Xiangyu Guo Yong-hui Jiang Xiao-Jiang Li Yong Q Zhang 

机构地区：[1]State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Bei- jing 100101, China [2]University of Chinese Academy of Sciences, Beijing 100101, China [3]Guangdong-Hongkong-Macao Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Lab- oratory, Jinan University, Guangzhou, Guangdong 510632, China [4]The Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China [5]Yuanxi Biotech lnc., Guangzhou, Guangdong 5010663, China [6]Department of Pediatrics and Department of Neurobiology, Duke University, Durham, NC 27710, USA [7]Department of Human Genetics, Emorv University School of Medicine. Atlanta. GA 30322. USA

出　　处：《Cell Research》2017年第10期1293-1297,共5页细胞研究（英文版）

基　　金：We thank Drs Weixiang Guo, Xiaoming Wang and Zhiheng Xu for discussion, Ruxiao Xing, Xudong Liu and Jinquan Gao for technical assistance, Yafeng Luo （Guangzhou Yuanxi Biotech Co., Ltd） for animal resource and care, and Samuel Hulbert for critical reading of the manuscript. The project was supported by the Min- istry of Science and Technology of China （2014CB942803 and 2016YFA0501000）, the Strategic Priority Research Program of the Chinese Academy of Sciences （XDB02020400）, and the National Natural Science Foundation of China （31110103907, 91332206 and 31490592）.

摘　　要：Dear Editor, Despite substantial progress made toward under- standing the molecular changes contributing to autism spectrum disorders （ASD）, the neuropathophysiology underlying ASD remains poorly understood [1, 2]. Struc- tural brain imaging in humans is valuable, but lacks res- olution at the cellular level. Studies of neuropathology in humans have been hampered by the lack of high quality postmortem brains from individuals with ASD [2]. For more than decades, mutant mice have served as major tools to dissect the pathophysiology of ASD because of the wealth of molecular and neurobiological techniques developed for studies with rodents.

关 键 词：非人灵长类动物 额叶皮层 神经 分子生物学 蛋白 突触 中断 水平分辨率 

分 类 号：Q959.848[生物学—动物学] S858.959[农业科学—临床兽医学]