遵义汉族白细胞介素6基因-572C/G多态与混合型高脂血症的相关性  

Association of interleukin-6 gene-572C/G polymorphism with combined hyperlipidemia of the Han Nationality in Zunyi

作　　者：吕纯莉[1] 张志敏[2] 耿争光 杨昌伟 肖代敏[1] LV Chun-Li ZHANG Zhi-Min GENG Zheng-Guang YANG Chang-Wei XIAO Dai-Min(Clinical Laboratory, Affiliated Hospital of Zunyi Medical College Medical Genetics Department Grade 2012, De- partment of Clinical Medicine Grade 2010, Department of Medical Laboratory, Zunyi Medical College, Zunyi, Guizhou 563099, China)

机构地区：[1]遵义医学院附属医院检验科 [2]遵义医学院医学遗传学教研室 [3]遵义医学院 [4]遵义医学院检验系

出　　处：《中国动脉硬化杂志》2017年第9期904-908,共5页Chinese Journal of Arteriosclerosis

基　　金：贵州省科技厅项目(黔科合J字LKZ[2012]39号);遵义医学院大学生创新创业训练计划项目(院发[2014]5828)

摘　　要：目的探讨白细胞介素6(IL-6)基因-572C/G多态与遵义汉族混合型高脂血症的相关性。方法用聚合酶链反应产物直接测序分析100例混合型高脂血症患者和100例正常对照者IL-6基因-572C/G多态性。结果混合型高脂血症组和正常对照组年龄、性别、血糖差异无统计学意义(P>0.05),混合型高脂血症组血脂指标明显高于正常对照组(P<0.05);IL-6基因-572C/G基因型频率和等位基因频率在混合型高脂血症组与正常对照组间差异无统计学意义(P>0.05);总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)、甘油三酯(TG)/高密度脂蛋白胆固醇(HDLC)和TC/HDLC值在正常对照组组内CC与CG+GG基因型个体间差异具有统计学意义(P<0.05);两组内其他血脂指标无统计学差异(P>0.05)。结论 IL-6基因-572C/G多态与遵义汉族人群混合型高脂血症发病不存在相关性;IL-6基因-572G等位基因不是混合型高脂血症的独立危险因素。Aim To investigate the relativity of interleukin-6 gene-572C/G polymorphism with combined hyper- lipidemia in Zunyi Han Nationality. Methods -572C/G polymorphism of 100 combined hyperlipidemia patients and 100 healthy individuals were tested by sequencing after polymerase chain reaction. Results Age, gender and blood sugar had no statistical differences between patients group and normal group, but blood lipid index of combined hyperlipi- demia patients was higher than healthy individuals（P〈0.05）. The genotype frequency and allele gene frequency of IL-6 gene -572C/G showed no correlation between patients group and normal groups （P〉0.05）. Total cholesterol （TC）, low density lipoprotein cholesterol （LDLC）, triglyceride （TG）/high density lipoprotein cholesterol （HDLC） and TC/HDLC were different between CC and CG＋GG genotype in the normal group（P〈0.05） ; others had no differences among the two groups. Conclusion There was no relativity between IL-6 gene -572C/G polymorphism and combined hyperlipidemia in Zunyi Han Nationality. The -572G gene was not an independent risk factor for combined hyperlipidemia.

关 键 词：白细胞介素6基因 -572C/G多态 混合型高脂血症 遵义汉族 

分 类 号：R5[医药卫生—内科学]