单倍体相合造血干细胞移植治疗幼年型粒单核细胞白血病的临床研究  

Clinical Study on Treatment of Juvenile Myelomonocytic Leukemia with Haploidentical-Hematopoietic Stem Cell Transplantation

作　　者：丁丽[1] 朱恒[2] 韩冬梅[1] 王志东[1] 郑晓丽[1] 董磊[1] 闫洪敏[1] 刘静[1] 朱玲[1] 薛梅[1] 郭子宽[3] 王恒湘[1] 

机构地区：[1]中国人民解放军空军总医院血液科,北京100142 [2]军事医学科学院基础医学研究所,北京100850 [3]军事医学科学院放射与辐射医学研究所,北京100850

出　　处：《中国实验血液学杂志》2017年第5期1524-1527,共4页Journal of Experimental Hematology

基　　金：国家自然科学基金青年项目(81500083;81101342);国家自然科学基金面上项目(81371945;81572159);北京市自然科学基金面上项目(7132133);空军总医院院级课题(KZ2014023;KZ2016022)

摘　　要：目的:探讨单倍体相合造血干细胞移植术(haploidentical-HSCT)治疗幼年型粒单核细胞型白血病(JMML)的效果。方法:对6例JMML接受了haploidentical-HSCT患者的造血植入、移植物抗宿主病(GVHD)发生率、并发感染、原发病复发及生存情况等临床资料进行了回顾分析。结果:6例患者全部为男性。供体均为亲缘性单倍体相合供者。接受了haploidentical-HSCT的6位患者的造血干细胞均成功植入,其中2例JMML死于移植后肺部感染,其余4例无病生存至今。3例发生急性GVHD,1例发生慢性GVHD。总体生存率66.7%,无病生存率66.7%,复发率0。结论:haploidentical-HSCT是治疗JMML的有效手段。Objective： To analyze the therapeutic efficacy of haploidentical-hematopoietic stem cell transplantation（ hi-HSCT） for patients with juvenile myelomonocytic leukemia（JMML）. Methods： The engraftment of hematopoietic stem cells,incidence of graft versus host disease（ GVHD）,infection,relapse,and survival of 6 JMML patients received hi-HSCT were retrospectively analyzed. Results： Six（6 males） JMML patients received hi-HSCT from haploHLA-matched related donors. The results showed that the hematopoictic stem cells in all 6 patients were grafted successfully. Two cases of JMML died of pulmenary infections,other 4 cases survive without disease. Acute GVHD occurred in 3 patients and chronic GVHD occurred in 1 patients. The overall survival,disease free survival and relapse rates were 66. 7%,66. 7%,0%,respectively. Conclusion： The hi-HSCT is an effective method for treatment of patients with JMML,but there also is a serial problems to be resolved.

关 键 词：单倍体造血干细胞移植术 幼年型粒单核细胞白血病 临床研究 

分 类 号：R457.7[医药卫生—治疗学] R733.7[医药卫生—临床医学]