孕妇IgG效价与不同血型新生儿溶血并发症的相关性分析  

Analysis of Correlation between IgG Titer of Pregnant Women and Neonatal Hemolytic Complications of Different Blood Groups

作　　者：叶海辉[1] 黄洪海 王晓霖[1] 皮佑珺[1] 

机构地区：[1]湖北省襄阳市中心医院输血科,湖北襄阳441021

出　　处：《中国实验血液学杂志》2017年第5期1532-1536,共5页Journal of Experimental Hematology

基　　金：湖北省卫生计生采供血基金资助项目(WJ2015CB011)

摘　　要：目的:探讨孕妇IgG效价与不同血型新生儿患溶血病(hemolytic disease of newborn,HDN)的相关性。方法:选取2014年5月-2015年1月在我院进行产检的O型血孕妇400例,且夫妻双方血型不同,在检查过程中对孕妇的IgG效价进行了检测,并且追踪孕妇产后新生儿溶血病的发生情况;根据新生儿是否出现HDN分为两组:HDN组和非HDN组。HDN组85例,非HDN组315例,并对IgG效价与其相关性进行系统的研究分析。结果:将产检过程中孕妇IgG效价分为<1∶64、1∶64、1∶128、1∶256和1∶512 5组,对IgG效价>64 4组的新生儿HDN发病率与IgG效价<64的新生儿HDN发病率分别比较显示,ABO-HDN的患病率分别为96.9%、79.6%、63.7%和28.8%,孕妇IgG效价与新生儿ABO溶血病的发生存在着一定的相关性,即随着IgG效价的升高,新生儿溶血病的发病率有升高的趋势(r=0.8832)。4组中新生儿的HDN发病的风险均高于IgG效价<64新生儿的HDN组。结论:孕妇IgG效价与ABOHDN的发病率有一定的相关性,因此对于IgG效价高的孕妇在产前进行效价的控制对于降低新生儿溶血病的发病率具有重要的临床意义。Objective： To study the relationship between IgG titer of pregnant women and hemolytic disease of newborn（HDN） with different blood groups. Methods： Four hundred pregnant women,including pregnant women with type O blood,were selected from May 2014 to January 2015 in our hospital for inspection and a couple of different blood groups,the IgG titer of pregnant women were detected in the inspection process. According to neonatal HDN,newborns were divided into 2 groups： HDN group（85 cases） and non-HDN group（315 cases）. The incidence of postpartum neonatal hemolytic disease was tracked and the correlation of IgG titers with HDN were systematically analyzed. Results： In the production and inspection process,the IgG titer in pregnant women was divided into 1∶ 64,1∶ 64,1∶ 128,1∶ 256 and greater than or equal to 1∶ 512 five groups. the comparison of HDN incidence rate in 4 groups of IgG titer 64 and IgG titer 1∶ 64 group showed that the prevalence of ABO hemolytic disease of newborn were 96. 9%,79. 6%,63,7% and28. 8%,there was a certain correlation of pregnant women IgG titers with ABO hemolytic disease of the newborn,that is,with the increase of IgG titer,the incidence of hemolytic disease of newborns increased in certain degree（r = 0. 8832）,the risk in 4 groups of neonatal HDN was higher than that in IgG titer 1∶ 64 of IgG titer 64 HDN group. Conclusion：There is a certain corelation between prevalence of ABO-HDN and IgG titer of pregnant women. For these pregnant women,the control of the pregnant women IgG titer has a positive clinical significance to reduce the incidence of hemolytic disease of the newborn.

关 键 词：孕妇IgG效价 不同血型 新生儿溶血 相关性分析 

分 类 号：R722.18[医药卫生—儿科]