Sonic Hedgehog信号通路在心血管系统疾病中的研究进展  

Research Progress of Sonic Hedgehog Signaling Pathway in Cardiovascular Diseases

作　　者：张苑[1] 张伟伟 陈磊磊[1] 

机构地区：[1]南京医科大学第一附属医院心内科,南京210029

出　　处：《医学综述》2017年第20期3989-3994,4000,共7页Medical Recapitulate

基　　金："六大人才高峰"第十一批高层次人才选拔培养自主计划(WSN-005)

摘　　要：Sonic Hedgehog(Shh)在Hedgehog家族中表达最为广泛,Shh信号通路存在于多种动物体内,Shh信号通路对调节心肌细胞发育、心血管系统形成、细胞分化、组织损伤后修复、组织再生等过程发挥重要作用,其异常激活参与多种肿瘤细胞的发生过程。近年来研究发现,Shh信号通路不仅参与胚胎时期的心肌细胞发育、心血管系统形成,也可促进心肌细胞/血管再生、招募内皮祖细胞移位至损伤区域、减少再灌注心律失常,对缺血缺氧后心肌细胞的保护起关键作用。总结Shh信号通路转导机制及其在心血管系统疾病中发挥的作用,有望为先天性心脏病的修复以及缺血性心脏病的分子靶向治疗提供新思路。Sonic Hedgehog（Shh） is the most widely expressed in the Hedgehog family,Shh signaling pathway exists in a variety of animals,and the Shh signaling pathway plays an important role in regulating myocardial cell development,cardiovascular system formation,cell differentiation and tissue repair after injury and tissue regeneration process,and its abnormal activation occurs in a variety of tumor cells.In recent years,studies found that Shh signaling pathway not only participates in embryonic cardiac development,the cardiovascular system formation,but also can promote myocardial cell regeneration,recruit vascular/endothelial progenitor cell to injury sites,reduce the displacement of reperfusion arrhythmia,and protect myocardial cells after hypoxia ischemia.Summary of the mechanism of Shh signaling pathway and its role in cardiovascular diseases,is expected to provide a new approach for the repair of cardiovascular disease and the molecular targeted therapy of ischemic cardiac disease.

关 键 词：SHH 心血管系统疾病 心肌细胞 

分 类 号：R541.1[医药卫生—心血管疾病] R541.4[医药卫生—内科学]