线粒体自噬的发生机制及其在脑缺血/再灌注损伤中作用的研究进展  

Research Progress of Mechanism of Mitophagy and Its Effect in Cerebral Ischemia Reperfusion Injury

作　　者：吴新伟 谭永星[1] WU Xin- wei TAN Yongxing.(Department of ICU,Affiliated Hospital of Guilin Medical University, Guilin 541004, China)

机构地区：[1]桂林医学院附属医院重症医学病区,广西桂林541004

出　　处：《医学综述》2017年第21期4173-4177,共5页Medical Recapitulate

基　　金：国家自然科学基金(81260206);广西自然科学基金(2013GXNSFAA019155;2015GXNSFAA139130);广西壮族自治区卫生和计划生育委员会自筹科研课题(Z2016320)

摘　　要：自噬是在溶酶体中降解细胞内蛋白质和细胞器,产生氨基酸和脂肪酸,供细胞再次利用的过程。其中线粒体自噬,不同于传统自噬,是选择性去除受损线粒体的一种靶向自噬。线粒体自噬的发生机制,与线粒体形态动力学有关且受到线粒体自噬信号通路的调节。线粒体自噬与脑缺血/再灌注损伤的病理生理过程有密切联系。一方面脑缺血/再灌注的过程能诱导线粒体自噬的产生,另一方面线粒体自噬又对脑缺血/再灌注损伤的转归有重要影响。Autophagy is the process of degrading intracellular proteins and organelles in lysosomes, which can produce amino acids and fatty acids for the re-utilization of cells. Mitophagy, unlike classical autophagy, is a targeted autophagy which can selectively remove damaged mitochondria. The mechanism of mitophagy is related to mitochondrial morphological dynamics and is regulated by mitochondrial autophagy signaling pathway. Mitophagy is closely related to the pathophysiologi- cal processes of cerebral ischemia-reperfusion injury. On one hand, the process of cerebral ischemia reperfusion can induce the generation of mitophagy; on the other hand, mitophagy plays an important role in the prognosis of cerebral ischemia- reperfusion injury.

关 键 词：自噬 线粒体自噬 脑缺血/再灌注 

分 类 号：R34[医药卫生—基础医学] R743.9