正交试验优化复方胃炎胶囊中药材的水提工艺  

Optimization of Water Extraction Technology for the Medicinal Materials in Compound Gastritis Capsule by Orthogonal Test

作　　者：郑姣妮[1] 刘玲[1] 何道惠 

机构地区：[1]重庆市急救医疗中心/重庆市第四人民医院药剂科,重庆400014 [2]四川省中医药研究院分析测试中心,成都610041

出　　处：《中国药房》2017年第31期4438-4440,共3页China Pharmacy

基　　金：重庆市卫生局中医药科研计划项目(No.2012-2-31)

摘　　要：目的:优化复方胃炎胶囊中药材的水提工艺。方法:采用正交试验,以干膏中芍药苷含量、丹酚酸B含量与干膏质量的综合评分为评价指标,考察加水量、煎煮时间和煎煮次数对水提工艺的影响,并进行验证试验。结果:优化的水提工艺为煎煮3次、每次120 min、每次加10倍量水;验证试验中综合评分平均值为909.19(RSD=1.84%,n=3)。结论:优化的水提工艺稳定、可行,可用于复方胃炎胶囊中各药材的提取。OBJECTIVE：To optimize the water extraction technology for the medicinal materials in Compound gastritis capsule. METHODS：Orthogonal test was adopted. Using the comprehensive score of contents of paeoniflorin,salvianolic acid B and weight of dry extract as evaluation index,effects of adding water amount,decoction time and times on water extraction technology were investigated,and verification test was conducted. RESULTS：Optimized water extraction technology was as follows as decocting for 3 times,120 min each time and adding 10-fold water each time. In verification test,average comprehensive score was909.19（RSD=1.84%,n=3）. CONCLUSIONS：Optimized water extraction technology is stable and feasible,and can be used for the water extraction for each medicinal material in Compound gastritis capsule.

关 键 词：复方胃炎胶囊 正交试验 提取工艺 芍药苷 丹酚酸B 

分 类 号：R284.2[医药卫生—中药学]