赖氨酸锗和环磷酰胺合用对小鼠S-180肉瘤抑瘤作用  

COMBINED ANTITUMOR EFFECT OF LYSINE-GERMANIUM AND CYCLOPHOSPHAMIDE ON S-180 SARCOMA IN MICE

作　　者：陈红专[1] 孙琛[1] 俞霭瑶[1] 金正均[1] 

机构地区：[1]上海第二医科大学药理教研室,200025

出　　处：《中国药理学通报》1991年第1期32-35,共4页Chinese Pharmacological Bulletin

摘　　要：赖氨酸锗(Ge401)是国内新近研制的含微量元素锗有机物。测得小鼠gi LD_(50)为9.26g/kg,ip LD_(50)为5.62g/kg;采用ig、ip、iv途径给药,对小鼠S-180肉瘤均有显著抑瘤作用,其中iv给药的抑瘤率(55%)最高;Ge401(30mg/kg·5d^(-1))和环磷酰胺(30mg/kg·2d^(-1))合用具有明显增强抑瘤作用。Lysine-germanium ( Ge401 ) was a newly synthesized organoger-manium compound in China. The LD50 of Ge401 for mice was 9.26 and 5.62 g/kg po and ip administrations. The inhibition rates of subcutaneously transplanted S-180 sarcoma in mice were 25%, 32% and 55% respectively when ip, po and iv administrations of Ge401 were used. The antitumor activity of cyclophosphamide (30 mg/kg· 2d-1, ip ) in S-180 bearing mice was significantly potentiated by Ge401 (30 mg/kg·d-1, iv ) .

关 键 词：赖氨酸锗 环磷酰胺 抑瘤作用 

分 类 号：R965[医药卫生—药理学]