Easily fabricated and recyclable Pd&Cu@Al catalyst for gram-scale phosphine-free Heck reactions with high TON  

作　　者：Dongliang Zhang Zheng Wei Lei Yu 

机构地区：[1]Institute of Pesticide,School of Horticulture and Plant Protection,Yangzhou University [2]School of Chemistry and Chemical Engineering,Yangzhou University

出　　处：《Science Bulletin》2017年第19期1325-1330,共6页科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China (21202141);Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions;the Young Science and Technology Talent Support Project of Jiangsu Province (Lei Yu);the High Level Talent Support Project of Yangzhou University (Topnotch Talent, Lei Yu);the Open Project Program of Jiangsu Key Laboratory of Zoonosis (R1509);the Testing Centre of Yangzhou University

摘　　要：A unique Pd＆Cu@Al catalyst was easily fabricated just by immersing commercial aluminum foil in a mixed xylene solution of PdC12 and CuCl2. The catalyst fabrication process led to aluminum oxide coatings in situ, which supported the metal nanoparticles and enhanced their catalytic activities for the phosphine-free Heck reaction of awl halides and styrenes with high turnover number （TON） up to 3.9×10^5. The reaction can be scaled up to at least 100 mmol and has been applied in modification of drug Lapatinib＇s intermediate with low metal residue. This novel catalyst is of good application potential in industrial production because it was extremely easy to be recycled, in regardless of the generation of the insoluble impurities or tars during the reaction processes.A unique Pd&Cu@Al catalyst was easily fabricated just by immersing commercial aluminum foil in a mixed xylene solution of PdCl_2 and CuCl_2. The catalyst fabrication process led to aluminum oxide coatings in situ, which supported the metal nanoparticles and enhanced their catalytic activities for the phosphine-free Heck reaction of aryl halides and styrenes with high turnover number(TON) up to 3.9×10~5. The reaction can be scaled up to at least 100 mmol and has been applied in modification of drug Lapatinib's intermediate with low metal residue. This novel catalyst is of good application potential in industrial production because it was extremely easy to be recycled, in regardless of the generation of the insoluble impurities or tars during the reaction processes.

关 键 词：Catalyst recoveryPalladiumnanoparticlesAluminum oxidePhosphine-freeSustainable chemistryHeck reaction 

分 类 号：TQ426[化学工程]