CG与CRP在肝炎及ICP患者中的相关性以及临床意义  

Correlation between CG and CRP in hepatitis and ICP patients and its clinical implication

作　　者：吕英[1] 杨林苗 王国英[1] 

机构地区：[1]新昌县人民医院检验中心生化室,浙江绍兴312500

出　　处：《健康研究》2017年第5期517-519,共3页Health Research

摘　　要：目的分析探讨甘胆酸(Cholyglycine,CG)与血清C反应蛋白(C-reactionprotein,CRP)相关性以及临床意义。方法 300例肝病患者(肝病组)根据患者病情分为轻度肝炎组、中度肝炎组、重度肝炎组各100例,240例妊娠期肝内胆汁淤积症(intrahepaticcholestasisofpregnancy,ICP)患者(妊娠组)根据病情分为轻度ICP组、中度ICP组、重度ICP组各80例,100例健康人员作为正常组;比较各组CG、CRP水平。结果在肝病组及妊娠组中,CG与CRP呈明显正相关性(P<0.05);CG、CRP水平为健康组<轻度肝炎组<中度肝炎组<重度肝炎组,健康组<轻度ICP组<中度ICP组<重度ICP组,差异均有统计学意义(P<0.05)。经logstic多因素分析显示CG水平<8.65(mg/L)和CRP水平<3.65(mg/L)是新生儿发生胎儿窘迫、Apgar评分<7、羊水粪染、早产的保护因素。结论在肝病患者和ICP患者中,CG与CRP呈显著正相关性,可用于临床诊断和判断肝炎、ICP病情,并预测ICP产妇及新生儿预后。Objective To examine the correlation between CG and CRP in hepatitis and ICP patients and its clinical implication. Method Firstly,300 patients with liver disease were divided into three groups according to the severity of disease,namely,mild hepatitis group（ n = 100）,moderate hepatitis group（ n = 100） and severe hepatitis group（ n =100）; 240 women in pregnancy with ICP were divided into three groups,namely,mild ICP group（ n = 80）,moderate ICP group（ n = 80）,and severe ICP group（ n = 80）; these groups served as the experimental; 100 health people were chosen as the control. Each group＇s CG and CRP levels were compared. Findings The levels of CG and CRP were significantly correlated with CG and CRP in the experimental groups（ P〈0. 05）. The levels of CG and CRP were significantly higher in the control group,the mild hepatitis group,the moderate hepatitis group,where ICP group moderate ICP group severe ICP group. The difference was statistically significant（ P〈0. 05）.Logistic multivariate analysis showed that CG level 8.65（ mg/L） and CRP level 3.65（ mg/L） were the protective factors contributing to neonatal fetal distress,Apgar score 7,and amniotic fluid. Conclusion There is a significant positive correlation between CG and CRP in patients with liver disease and ICP. It can be used for clinical diagnosis and judgment of hepatitis and ICP and to predict the prognosis of ICP patients and neonates.

关 键 词：甘胆酸 C反应蛋白 肝病 妊娠期肝内胆汁淤积症 

分 类 号：R512.62[医药卫生—内科学]