结核丸联合莫西沙星治疗临床研究  

Effect of Tuberculosis Pill and Moxifloxacin in the Treatment of Multi-drug Resistant Tuberculosis

作　　者：孙冰[1] 

机构地区：[1]新乡医学院第一附属医院结核科,河南新乡453000

出　　处：《亚太传统医药》2017年第21期135-137,共3页Asia-Pacific Traditional Medicine

摘　　要：目的:研究结核丸联合莫西沙星治疗耐多药肺结核患者的临床疗效。方法:将84例耐多药肺结核患者随机分为观察组和对照组各42例,对照组患者给予盐酸莫西沙星片,观察组患者加用结核丸。观察比较两组患者的临床疗效,治疗前后T细胞亚群、干扰素(INF)γ、白细胞介素-4(IL-4)水平及不良反应发生情况。结果:观察组患者治疗总有效率明显高于对照组(P<0.05);治疗后,两组患者CD4^+、CD3^+、CD4^+/CD8^+、INF-γ水平均明显改善,IL-4水平明显低于治疗前,且观察组优于对照组(P<0.05)。两组患者不良反应发生率无统计学差异(P>0.05)。结论:结核丸联合莫西沙星治疗耐多药肺结核疗效明显,且安全性高,值得临床推广应用。Objective： To investigate the effect observation and influence on immunologic function of tuberculosis pill and moxifloxa- cin in treating multi-drug resistant tuberculosis. Methods. 84 cases with multi-drug resistant tuberculosis were selected and divided into observation group and control group, 42 cases in each group. Control group was given moxifloxacin and observation group was given tuberculosis pill and moxifloxacin. Compare the clinic effect. T cell subset. INF-γ, IL-4 level, adverse reaction condition before and after treatment of the two groups. Results：Total efficiency of observation group was higher than control group （P〈0.05）. After treatment, CD3＋ , CD4＋ . CD4＋/CD8＋ , INF-γ level of the two groups were higher than those before treatment, observation group was higher than control group （P〈0.05） ; IL-4 level of the two groups were lower than those before treatment, observation group was lower than control group, the difference was statistic significant （P〈0.05）. Comparison of adverse reaction rate between the two groups（P〉0.05）. Conclusion：Based on general treatment, tuberculosis pill and moxifloxacin is better than simple moxifloxacin in treating multi-drug resistant tuberculosis and the safety is equal.

关 键 词：耐多药肺结核 结核丸 莫西沙星 免疫功能 

分 类 号：R249[医药卫生—中医临床基础]