Complex role of matrix metalloproteinases in angiogenesis  

作　　者：SANG QING XIANG AMY(Biochemistry Division, Department of Chemistry, Florida State University, Tallahassee, Florida 32306-4390, USA) 

出　　处：《Cell Research》1998年第3期171-177,共7页细胞研究（英文版）

摘　　要：Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMP) play a significant role in regulating angiogenesis, the process of new blood vessel formation. Interstitial collagenase (MMP-1), 72 kDa gelatinase A/type IV collagenase (MMP-2), and 92 kDa gelatinase B/type IV collagenase (MMP-9) dissolve extracellular matrix (ECM) and may initiate and Promote angiogenesis. TIMP-1, TIMP-2, TIMP-3, and possibly,TIMP-4 inhibit neovascularisation. A new paradigm is emerging that matrilysin (MMP-7), MMP-9, and metalloelastase (MMP-12) may block angiogehesis by converting plasndnogen to angiostatin, which is one of the most potent angiogenesis antagonists. MMPs and TIMPs play a complex role in regulating angiogenesis. An understanding of the biochemical and cellular pathways and mechanisms of angiogenesis will provide importal information to allow the control of angiogenesis, e.g. the stimulation of angiogenesis for coronary collateral circulation formation; while the inhibition for treating arthritis and cancer.

关 键 词：COLLAGENASES tissue inhibitors of metalloproteinases NEOVASCULARIZATION plasminogen angiostatin converting enzymes extracellular matrix 

分 类 号：R543.02[医药卫生—心血管疾病] R730.2[医药卫生—内科学]