350例儿科住院患者的抗菌药物临床应用分析  

Analysis of 350 Cases of Antimicrobial Agents Clinical Use in Pediatric Inpatients

作　　者：张琳[1] 杨波 王来成 

机构地区：[1]徐州市第一人民医院药剂科,江苏徐州221002 [2]徐州市食品药品监督管理局,江苏徐州221018 [3]徐州医科大学附属医院药学部,江苏徐州221006

出　　处：《中国药物警戒》2017年第9期559-561,565,共4页Chinese Journal of Pharmacovigilance

摘　　要：目的了解我院儿科住院患者抗菌药物使用情况,评价其临床应用合理性,为临床合理用药提供参考依据。方法利用医院HIS系统抽取2016年1~6月份使用抗菌药物的归档住院病历350份。统计分析抗菌药物使用品种、给药频次、联合用药及病原学送检等。结果单一使用抗菌药物128例,占36.57%;二联用药222例,占63.43%;病原学送检率为33.14%,品种选择以青霉素类、头孢菌素类及大环内酯类为主。结论儿科住院患者抗菌药物使用较合理,抗菌药物使用起点过高、给药频次过低、联用比例较高,非感染性疾病无指征使用抗菌药物等不合理现象,仍需采取有效干预措施,进一步促进临床合理用药。Objective To investigate the application of antibacterial agents in pediatric inpatients in our hospital and evaluate the rationality to provide references for clinic. Methods 350 outpatients＇ medical records were selected randomly by HIS from January to June in 2016. The indexes in terms of antibacterial selection, frequency of medication, combination therapy and pathogenic examination were analyzed. Results 128 cases were treated with one kind of antibiotics and the ratio was 36.57%. 222 cases were treated with combination use of antibiotics and the ratio was 63.43%. The inspection ratio of pathogenic bacteria was 33.14%. Penicillins, cephalosporins, and macrolides ranked top 3 in terms of use frequency. Conclusion Clinical management of the use of antibacterials is mainly rational, but the irrational administration of antibiotics in pediatric outpatients is still present in terms of drug selection, combination therapy, frequency of medication and improper drug selection. The supervision of using antibiotics should be highlighted to enhance the clinical management of rational use of antibacterials.

关 键 词：儿科 住院患者 抗菌药物 合理用药 

分 类 号：R969.3[医药卫生—药理学]