研究盐酸坦索罗辛联合速尿注射液在体外冲击波碎石后治疗输尿管不同部位结石中的临床效果及不良反应  

Study on clinical effect and adverse reaction of tamsulosin hydrochloride combined with furosemide injection after extracorporeal shock wave lithotripsy in the treatment of ureteral calculi in different parts

作　　者：罗金玉[1] 

机构地区：[1]沈阳市第四人民医院泌尿外科,110031

出　　处：《中国现代药物应用》2017年第20期95-97,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨研究盐酸坦索罗辛联合呋塞米(速尿)注射液在体外冲击波碎石后治疗输尿管不同部位结石中的应用效果以及不良反应发生情况。方法 68例输尿管结石患者为研究对象,根据治疗方法不同分为观察组与对照组,每组34例。两组均采取体外冲击波碎石治疗,对照组采取常规治疗,并使用速尿注射液;观察组加用盐酸坦索罗辛进行治疗。观察两组治疗情况。结果对照组患者,中上段结石排出时间为(8.3±1.2)d,下段结石排出时间为(7.1±1.6)d;观察组患者,中上段结石排出时间为(5.4±1.4)d,下段结石排出时间为(4.3±1.8)d;观察组患者中上段结石排出时间及下段结石排出时间均明显短于对照组,差异均具有统计学意义(P<0.05)。对照组患者,中上段结石清除12例,占66.7%(12/18),下段结石清除10例,占62.5%(10/16);观察组患者,中上段结石清除18例,占94.7%(18/19),下段结石清除14例,占93.3%(14/15);观察组患者中上段结石及下段结石的结石清除率均明显高于对照组,差异均具有统计学意义(P<0.05)。两组中上段结石及下段结石患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论对实施体外冲击波碎石治疗的输尿管不同部位结石患者联合使用盐酸坦索罗辛及速尿注射液可促进结石的排出,提高结石清除率,且不良反应发生率较低,具有推广价值。Objective To investigate the application effect and occurrence of adverse reactions of tamsulosin hydrochloride combined with furosemide（furosemidum） injection after extracorporeal shock wave lithotripsy in the treatment of ureteral calculi in different parts. Methods A total of 68 ureteral calculi patients as study subjects were divided by different treatment methods into observation group and control group, with 34 cases in each group. Both groups received extracorporeal shock wave lithotripsy, and the control group also received conventional therapy and furosemide injection. The observation group also received tamsulosin hydrochloride. The treatment condition in two groups was observed. Results The control group had discharge time of middle and upper ureteral calculi as（8.3±1.2） d and discharge time of lower ureteral calculi as（7.1±1.6） d, while the observation group had discharge time of middle and upper ureteral calculi as（5.4±1.4） d and discharge time of lower ureteral calculi as（4.3±1.8） d. The observation group had obviously shorter discharge time of middle, upper and lower ureteral calculi than the control group, and their difference was statistically significant（P〈0.05）. The control group had 12 cases with removal of middle and upper ureteral calculi, accounting for 66.7%（12/18）, 10 cases with removal of lower ureteral calculi, accounting for 62.5%（10/16）. The observation group had 18 cases with removal of middle and upper ureteral calculi, accounting for 94.7%（18/19）, and 14 cases with removal of lower ureteral calculi, accounting for 93.3%（14/15）. The observation group had obviously higher clearance rate of middle, upper and lower ureteral calculi than the control group, and the difference was statistically significant（P〈0.05）. Both groups had no statistically significant difference in incidence of adverse reactions in patients with middle, upper and lower ureteral calculi（P〉0.05）. Conclusion Combination of tamsulosin hydrochloride and furosemi

关 键 词：盐酸坦索罗辛 呋塞米注射液 体外冲击波碎石 输尿管结石 不良反应 临床疗效 

分 类 号：R699.4[医药卫生—泌尿科学]