抗瘤酮A10在鼠体内的药物动力学研究  

PHARMACOKINETIC STUDIES OF ANTINEOPLASTON A10 IN RATS

作　　者：王厚全[1] 徐文方[1] 袁玉梅[1] 王维岳 

机构地区：[1]山东医科大学药化教研室,济南250012

出　　处：《中国药理学通报》1991年第1期60-62,共3页Chinese Pharmacological Bulletin

摘　　要：本文报道了~3H-抗瘤酮A10经1次灌胃及静脉注射后在鼠体内的药物动力学研究。实验给出了有关动力学参数,如t1/2β 16.5±3.5h,Vd61.42ml,β0.0435±0.0090h^(-1),α为0.1953±0.0745h^(-1);建立了数学模型;其血药浓度—时间曲线符合双室模型。抗瘤酮A10在体内分布以肝、肾、胃、生殖器、膀胱最高;在脂肪、肠、肌肉和脑中亦有较高浓度。This paper describes the pharmacokinetic properties of 3H-labelled Antineoplaston A10 ( AlO)following oral and intravenous administration in rats. The pharmacokinetic parameters were given and mathematical model was established by experiments . It was observed that the, concentration-time curves in blood accord with dicompart-ment model of pharmacokinetics . Organ distribution studies indicated greatest accumulation of radioactivity in liver, kidney, stomach, genitals and bladder and relatively high accumulation in fat, intestine, muscle and brains .

关 键 词：抗瘤酮A10 药物动力学 

分 类 号：R969.1[医药卫生—药理学]