麝香保心丸与阿托伐他汀钙对颈动脉粥样硬化的治疗效果  

Effects of shexiang baoxin pill and atorvastatin calcium on carotid atherosclerosis

作　　者：符少萍[1] 洪俊[1] 陈焕清[1] 杨雪梅[2] 陈玉成[1] Fu Shaoping Hong Jun Chen Huanqing Yang Xuemei Chen Yucheng(Department of Preventive Health Care, SUN Yat-sen Memorial Hospital of SUN Yat-sen University, Guangzhou 510120, China Department of Pharmacy, SUN Yat-sen Memorial Hospital of SUN Yat-sen University, Guangzhou 510120, China)

机构地区：[1]中山大学孙逸仙纪念医院预防保健科,广东广州510120 [2]中山大学孙逸仙纪念医院药剂科,广东广州510120

出　　处：《中国实用医刊》2017年第19期99-101,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨麝香保心丸与阿托伐他汀钙对颈动脉粥样硬化的疗效及其作用机制。方法选取颈动脉粥样硬化斑块患者120例，随机分为两组，每组60例。两组患者均予以常规治疗，每晚睡前口服阿托伐他汀钙20 mg；治疗组加服麝香保心丸2粒/次，3次/d，疗程6个月。每例患者均于治疗前、治疗后6个月检测颈动脉内膜-中层厚度（IMT）、颈动脉不稳定斑块数、空腹静脉血检测内皮素（ET）、一氧化氮（NO）和血脂水平。结果治疗后6个月，两组颈动脉IMT、不稳定斑块数、低密度脂蛋白胆固醇、总胆固醇水平较治疗前下降（P〈0.05），且治疗组低于对照组（P〈0.05）。治疗后，治疗组NO较治疗前升高（P〈0.05），ET较治疗前降低（P〈0.05）；NO较对照组治疗后升高（P〈0.05），ET较对照组治疗后降低（P〈0.05）。结论麝香保心丸可通过调节ET/NO失衡和血脂水平等机制，抑制内膜中层增生，减少不稳定斑块数目，与他汀类联用可协同延缓动脉硬化。Objective To investigate the effect of shexiang baoxin pill （SXBXP） and atorvastatin calcium on carotid atherosclerosis （CAS）and its mechanism. Methods One hundred and twenty patients with CAS were selected and randomly divided into two groups, with 60 cases in each group. All patients received conventional treatment about CAS and took atorvastatin calcium 20 mg per night. Patients in treatment group had orally SXBXP 2 pellets a time and 3 times per day. The treatment lasted for 6 months. Carotid intima-media thickness （IMT）, carotid atheromatous unstable plague number, fasting endothelin （ET）, nirtogen oxides （NO）and lipid level were observed before and after treatment. Results After six months of treatment, IMT and carotid atheromatous unstable plague number, LDL-C, TC in the two groups were lower than those before treatment （P 〈 0. 05 ）, and was lower than those of the control group （P 〈 0.05 ）. After treatment, NO increased and ET decreased in treatment group compared with those before treatment（P 〈 0. 05 ）. Compared with control group, NO increased and ET decreased in treatment group after treatment （P 〈 0. 05 ）. Conclusions SXBXP can regular the disbalance of ET/NO and lipid level to inhibit carotid intima-media hyperplasia obviously and reduce unstable plague number. The combination of SXBXP and atorvastatin calcium can promote the effect on carotid atherosclerosis.

关 键 词：麝香保心丸 颈动脉粥样硬化 内膜-中层厚度 阿托伐他汀钙 

分 类 号：R543.4[医药卫生—心血管疾病]