三七皂甙对急性脑缺血的保护作用  

EFFECTS OF PANAX NOTOGINSENG SAPONINS ON ACUTE CEREBRAL ISCHEMIA

作　　者：李麟仙[1] 王子灿[1] 黄志宏[2] 张玉敏[3] 魏均娴[4] 

机构地区：[1]昆明医学院病理生理教研室,云南650031 [2]桂林医学院病理生理教研室,541000 [3]青岛医学院病理生理教研室,266012 [4]昆明医学院植化研究室,650031

出　　处：《中国药理学通报》1991年第1期56-59,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助课题

摘　　要：三七总皂甙对沙土鼠脑缺血再灌流损伤有明显保护作用;能减少脑缺血45min再灌流6h的卒中指数,并降低再灌流24h的死亡率。三七总皂甙单体Rb_1对树鼩局部脑缺血有保护作用:能减轻树鼩局部脑缺血12h后的脑水肿,并降低缺血脑组织的钙含量及缩小梗塞范国,而三七总皂甙单体Rg_1的作用不明显。By 45 min ligation of the gerbils' bilateral carotid arteries and then 24h reperfusion, the effects of panax notogniseng saponins ( PNS ) and SOD on the stroke index of 45 min cerebral ischemia followed by reperfusion 24h were evaluated. The results indicated that PNS and SOD could decrease the stroke index and mortality dramatically.We speculated that the beneficial effect of PNS on cerebral damage folio-wing ischemia with reperfusion might be due to anti-free radical action. The effects of PNS, Rb1 Rg1 and nimodi-pine on focal cerebral ischemia were studied by 12h occlusion of middle cerebral artery in squirrel monkeys. Both Rb1 and nimodipi-ne alleviated the brain edema and calcium content in ischemic tissue significantly, and reduced the infarcted size, while the effect of Rg1 was not statistical. The results suggested that the anti-cerebral ischemia effect of Saponin Rb1 probably contributes to its calcium antagonism.

关 键 词：三七皂甙 脑缺血 保护 

分 类 号：R931.71[医药卫生—生药学]