右美托咪定改善术后认知功能障碍的机制及进展  

Dexmedetomidine improves postoperative cognitive dysfunction： mechanism and progress

作　　者：解康杰 方军[2] 连燕虹[2] 姜慧芳[2] 俞卫锋[3,4] Xie Kangjie Fang Jun Lian Yanhong Jiang Huifang Yu Weifeng(Medical College of Soochow University, 215000 Department of Anesthesiology, Zhejiang Caner Hospital, Hangzhou 310022, China Department of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medicol University, Shanghai 200438, China Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China)

机构地区：[1]苏州大学医学部,215000 [2]浙江省肿瘤医院麻醉科,杭州310022 [3]上海市东方肝胆外科医院麻醉科,200438 [4]上海交通大学医学院附属仁济医院麻醉科,200127

出　　处：《国际麻醉学与复苏杂志》2017年第10期925-929,共5页International Journal of Anesthesiology and Resuscitation

基　　金：浙江省医药卫生科技计划项目一般研究计划（2016KYA042）

摘　　要：背景术后认知功能障碍（postoperativecognitivedysfunction，POCD）是手术麻醉后出现的中枢神经系统并发症，常见于65岁以上的老年患者。目的分析总结右美托咪定（dexmedetomidine，Dex）改善老年患者POCD的可能机制及临床应用。内容简述POCD的流行病学资料及发病机制；详细分析Dex改善POCD的可能机制。趋向目前对于POCD的治疗还在探索之中，Dex能否改善POCD，需要进一步的研究和探索。Background Postoperative cognitive dysfunction （POCD） is a complication of the central nervous system after surgical anesthesia, and commonly seen in elderly patients over 65 years old. Objective To summarize and analyze the possible mechanisms by which dexmedetomidine （Dex） improves POCD and the clinical uses of Dex. Content This article briefly described the epidemiological materials and pathogenesis of POCD, and analyzed the possible mechanism by which Dex improves POCD in detail. Trend At present, the treatment of POCD is still being explored. Whether Dex can improve POCD needs further research and exploration.

关 键 词：右美托咪定 术后认知功能障碍 

分 类 号：R614[医药卫生—麻醉学]