胞浆羧肽酶1的研究进展  

The research advances of cytosolic carboxypeptidase 1

作　　者：刘婧[1] 张传领 肖瑞[1] LIU Jing ZHANG Chuanling XIAO Rui(Laboratory of Molecular Pathology, Inner Mongolia Medical University, Hohhot 010059, China College of Pharmacy, Inner Mongolia Medical University, Hohhot 010059, China)

机构地区：[1]内蒙古医科大学,内蒙古自治区分子病理学重点实验室,呼和浩特010059 [2]内蒙古医科大学药学院,呼和浩特010059

出　　处：《生命的化学》2017年第4期488-494,共7页Chemistry of Life

基　　金：国家自然科学基金项目(31260260;31760304)

摘　　要：胞浆羧肽酶1(cytosolic carboxypeptidase 1,CCP1)属于胞浆羧肽酶家族(cytosolic carboxypeptidases,CCPs)的M14亚族,在小脑浦肯野细胞、视网膜光感受体细胞、嗅球僧帽细胞的分化和发育等过程中具有重要作用。CCP1蛋白具有羧肽酶功能域、ATP/GTP结合域、核定位序列和锌指结构,参与体内蛋白质水解过程,对α-tublin等蛋白质C末端多聚谷氨酸链具有去谷氨酸化作用。此外,CCP1蛋白功能缺失将引起细胞凋亡与自噬、线粒体自噬、内质网应激等生理过程。本研究使用String数据库对CCP1蛋白在不同种属中的相互作用蛋白进行分析总结,发现CCP1与ATP6V0D1、ATP6V0D2很可能具有相互作用。本文全面系统的对CCP1的功能及其作用机制的研究内容进行了综述,为后续CCP1蛋白的研究提供线索。Cytosolic carboxypeptidase 1 is predicted to be a zinc carboxypeptidase of a new and diverse M14 subfamily. CCP1 contains a putative ATP/GTP binding domain and nuclear localization signals, and it is related to differentiation of cerebellar Purkinje cell and eye photoreceptor cell, olfactory bulb development, neuromuscular process, proteolysis, C-terminal protein deglutamylation and protein side chain deglutamylation. Furthermore, dsyfunction of CCP1 results in apoptosis, autophagy, mitophagy and ER stress. We use String Database to analyse interacted proteins of CCP1, then we find that ATP6V0D1 and ATP6V0D2 are probable interactions of CCP1. To provide more clues of researches about CCP1, here, we will review the researches of CCP1 and summarize its fuctions and mechanism.

关 键 词：CCP1/AGTPBP1/NNA1 胞浆梭肽酶 锌指结构 去谷氨酸化 神经退行性病变 雄性不育 pcd小鼠 

分 类 号：Q55[生物学—生物化学]