[^(14)C]吗丙嗪在小鼠全身分布的放射自显影  

AUTORADIOGRAPHIC STUDIES OF THE DISTRIBUTION OF〔^(14)C〕PROBIMANE IN MICE

作　　者：胡艳平[1] 张覃沐[1] 王庆端[1] 

机构地区：[1]河南省医学科学研究所,郑州450052

出　　处：《中国药理学通报》1991年第2期136-137,共2页Chinese Pharmacological Bulletin

摘　　要：小鼠iv〔^(14)C〕吗丙嗪3.7×10~5Bq/20g(5.62×10~7Bq/g)后0.5h的整体放射自显影中,以S_(37)肿瘤组织、肾脏,膀胱内和脊椎内的放射活性较高;皮肤、肺、肝、胃肠道及血管内较少。3h时除肿瘤组织,肾脏和胃肠道持续积聚外,其它组织均趋减少。12h只有肠道留有残迹,其它组织已无放射性。吗丙嗪在各组织内的分布与其疗效和毒性有关。Probimane was first synthesized and developed in Shanghai Institute of Materia Medica, Chinese Academy of Science as a novel antit umor agent. Male mice were injected iv 〔14C〕 probimane 3.7×105Bq/20g( 5.62× 107Bq/g ) . At 0.5h,higher radioactivities were found in S87 tumor, kidney, bladder, and vertebra, moderate in skim, lung, liver, blood vessel and gut. The radioactivities tended to decre-aseafter 3h except in the tumor, kidney, and gut in which radioactivities persisted. After 12h, only a trace of radioactivity was detected n intestine. The distribution of probimane correlated with its therepeutic efficacy and toxicity.

关 键 词：吗丙嗪 抗癌药 放射自显影 

分 类 号：R979.1[医药卫生—药品]