不同药物对大鼠多形核白细胞活性氧生成的影响  

EFFECTS OF DIFFERENT DRUGS ON THE GENERATION OF ACTIVE OXYGEN IN POLYMORPHONEUCLEAR LEUKOCYTES ( PMN_s ) FROM RATS

作　　者：吴勇杰[1] 李新芳[1] 

机构地区：[1]兰州医学院药理学教研室,兰州730000

出　　处：《中国药理学通报》1991年第2期121-124,共4页Chinese Pharmacological Bulletin

摘　　要：用化学发光法进行测定,BW-755C明显抑制f-MLP、调理化酵母多糖A和A_(23187)诱导的大鼠PMNs活性氧生成,吲哚美辛作用极弱。硝苯吡啶、硫氮卓酮和戊脉安低浓度抑制A_(23187)诱导的PMNs活性氧生成,不抑制A_(23187)、诱导的PMNs内游离钙增加。PGE_1对f-MLP诱导的PMNs活性氧生成有选择性的抑制作用。By the method of chemiluminescence, it was showed that BW-755C strongly inhibited the generation of active oxygen in PMNs stimulated by f-MLP, A23187 or opsonized zymosan A, while the inhibitory effect of indomethacin was quite weaker, Nifidipine, diltiazem and verapamil inhibited the generation of active oxygen in PMNs stimulated by A23187 at low concentration, but they did not block intracel-lular calcium ion increase stimulated by A23187. PGE1 was shown in to be a selective inhibitor of f-MLP-induced active oxygen production PMNs.

关 键 词：吲哚美辛 钙通道阻滞药 

分 类 号：R972.9[医药卫生—药品]