Mast Cell-Derived Exosomes at the Stimulated Acupoints Activating the Neuro-immune Regulation  

作　　者：CHEN Bo LI Ming-yue GUO Yi ZHAO Xue LIM Hui-min Calista 

机构地区：[1]Acu-moxibustion and Tuina Department of Tianjin University of Traditional Chinese Medicine,Tianjin(300193),China [2]Department of Clinical Practice Teaching,Tianjin University of Traditional Chinese Medicine,Tianjin(300193),China

出　　处：《Chinese Journal of Integrative Medicine》2017年第11期878-880,共3页中国结合医学杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.81403457 and No.81330088)

摘　　要：Exosomes are cell-derived vesicles that take part in intercellular signaling. Research has shown that acupuncture is closely related to affecting the functions of the mast cells in the local region of the acupoint, and stimulating the afferent nerve. Mast cells have a connection with the conduction within the meridians, and play an important role in immuno-regulation. The ＇synapse-like＇ connection between the mast cells and nerve endings is the basis for the exchange of information between these two tissues. Exosome mediates mast exchange of information between mast cells and the nerves, starting the process of neuro-immuno regulation. Therefore, we propose that mast cell-derived exosomes mediate the neuro-immuno regulation at the local site of acupuncture, and this is one of the key factors resulting in the effectiveness of acupuncture.Exosomes are cell-derived vesicles that take part in intercellular signaling. Research has shown that acupuncture is closely related to affecting the functions of the mast cells in the local region of the acupoint, and stimulating the afferent nerve. Mast cells have a connection with the conduction within the meridians, and play an important role in immuno-regulation. The ＇synapse-like＇ connection between the mast cells and nerve endings is the basis for the exchange of information between these two tissues. Exosome mediates mast exchange of information between mast cells and the nerves, starting the process of neuro-immuno regulation. Therefore, we propose that mast cell-derived exosomes mediate the neuro-immuno regulation at the local site of acupuncture, and this is one of the key factors resulting in the effectiveness of acupuncture.

关 键 词：mast cell-derived exosomes acupuncture neuro-immuno regulation 

分 类 号：R245[医药卫生—针灸推拿学]