自拟五虫散结膏外敷配合抗结核药物治疗淋巴结结核的临床研究  

Clinical study of external application of self-made Wuchongsan ointment combined with antituberculosis drugs in the treatment of lymph node tuberculosis

作　　者：郑辉 吴福仓 李晓华 谷强业 ZHENG Hui WU Fu-cang LI Xiao-hua et al.(Jining City Fourth People＇ s Hospital, Jining 272123, China)

机构地区：[1]济宁市第四人民医院,272123

出　　处：《中国实用医药》2017年第29期107-109,共3页China Practical Medicine

摘　　要：目的观察自拟五虫散结膏外敷配合抗结核药物治疗淋巴结结核的近期疗效。方法 176例淋巴结结核患者,随机分为治疗组(83例)与对照组(93例)。对照组常规应用HRZE方案(异烟肼、利福平、吡嗪酰胺、乙胺丁醇)抗结核治疗,治疗组在HRZE方案的基础上加用自拟五虫散结膏局部外敷治疗。观察两组临床治疗效果及不良反应发生情况。结果患者均按规定用药,治疗过程中无淋巴结破溃,且未进行手术治疗,无一例失访。治疗后第2、4、6、8周,治疗组治疗效果均明显优于对照组,差异具有统计学意义(U=5.094、5.897、6.611、6.766,P<0.05)。在临床治疗过程中,未发现患者发生明显皮肤过敏等不良反应,患者耐受性好。结论自拟五虫散结膏外敷配合抗结核药物治疗淋巴结结核,有提高近期疗效,且无明显不良反应,值得推广。Objective To observe the short-term efficacy of external application of self-made Wuchongsan ointment combined with anti-tuberculosis drugs in the treatment of lymph node tuberculosis.Methods A total of 176 lymph node tuberculosis patients were randomly divided into treatment group（83 cases） and control group（93 cases）.The control group received HRZE regimen（isoniazid,rifampicin,pyrazinamide and ethambutol） for anti-tuberculosis treatment,and the treatment group received external application of selfmade Wuchongsan ointment on the basis of HRZE regimen.Observation were made on clinical treatment effect and adverse reactions occurrence between two groups.Results All patients in this group were given prescribed medication.There were no lymph node ulceration during treatment,no surgical treatment,and no case lost.After 2,4,6 and 8 weeks of treatment,the treatment group had obviously better treatment effect than the control group,and the difference was statistically significant（U=5.094,5.897,6.611,6.766,P〈0.05）.In the course of clinical treatment,there was no obvious adverse reactions of obvious skin allergy,and the patients were well tolerated.Conclusion Combination of external application of self-made Wuchongsan ointment and anti-tuberculosis drugs in treating lymph node tuberculosis can improve short-term efficacy with no obvious adverse reactions.So it is worthy of promotion.

关 键 词：淋巴结结核 自拟 五虫散结膏 外敷 抗结核药物 

分 类 号：R522[医药卫生—内科学]