右旋布洛芬在儿童退热作用中的疗效观察  

Observation on efficacy of dexibuprofen for defervesce in children

作　　者：徐鸣浩 XU Ming-hao(Department of Emergency, Kunming City Children＇s Hospital, Kunming 650000, Chin)

机构地区：[1]昆明市儿童医院急诊科,650000

出　　处：《中国实用医药》2017年第29期111-113,共3页China Practical Medicine

摘　　要：目的观察右旋布洛芬治疗儿童发热的临床疗效。方法 420例发热患儿,以就诊先后顺序随机分为治疗组和对照组,每组210例。治疗组口服右旋布洛芬混悬液退热治疗;对照组口服布洛芬混悬液退热治疗,比较两组患儿的治疗效果及不良反应情况。结果治疗组患儿的治疗总有效率为89.52%,显著高于对照组的81.43%,差异具有统计学意义(P<0.05)。治疗组出现多汗5例,轻度恶心3例,轻度皮疹1例;对照组出现多汗76例,呕吐18例,轻度皮疹29例。治疗组的不良反应发生率4.29%低于对照组的58.57%,差异具有统计学意义(P<0.05)。两组停药后上述症状自行消失,均未见严重不良反应发生。结论右旋布洛芬在儿童退热治疗中具有用量小、效果好、不良反应少的特点,适合临床推广应用。Objective To observe the clinical efficacy of dexibuprofen in the treatment of fever in children.Methods A total of 420 fever children were divided by admission order into treatment group and control group,with 210 cases in each group.The treatment group was treated with oral administration of dexibuprofen suspension for defervesce,and the control group was treated with oral administration of ibuprofen suspension for defervesce.Comparison were made on treatment effect and adverse reactions condition between two groups.Results The treatment group had obviously higher total treatment effective rate as 89.52% than 81.43% in the control group,and the difference was statistically significant（P〈0.05）.The treatment group had 5 hyperhidrosis cases,3 mild nausea cases,1 mild skin rash case,while the control group had 76 hyperhidrosis cases,3 vomiting cases,29 mild skin rash cases.The treatment group had lower incidence of adverse reactions as 4.29% than 58.57% in the control group,and their difference was statistically significant（P〈0.05）.The symptoms disappeared spontaneously after withdrawal in two groups,and no serious adverse reactions occurred.Conclusion Dexibuprofen has the advantages of small dosage,good effect and less adverse reaction for defervesce in children,and it is suitable for clinical promotion and application.

关 键 词：右旋布洛芬 退热 疗效 儿童 

分 类 号：R720.597[医药卫生—急诊医学]