左旋四氢巴马汀对麻醉大鼠血流动力学影响  

EFFECTS OF L-THP ON HEMODYNAMICS IN ANAESTHETIZED RATS

作　　者：吴绍光[1] 李晓兰[1] 任世兰[1] 赵国举[1] 

机构地区：[1]同济医科大学郧阳医学院药理教研室,十堰442000

出　　处：《中国药理学通报》1991年第2期153-155,共3页Chinese Pharmacological Bulletin

摘　　要：L-THP 6mg/kg iv仅显著降低麻醉大鼠血压,LVP-过性降低。iv L-THP 18mg/kg在显著降低血压的同时伴有LVP,±(dP/dt)_(max),(dP/dt)P^(-1)降低及HR减慢。但血压下降程度比心室收缩性能下降为大。L-THP依剂量降低DAP,且降低程度大于SAP。表明L-THP能降低外周阻力,大剂量时对心脏收缩性能有抑制作用。Hemodynamic study of L-THP in anaesthetized rats showed that 6 mg/kg iv decreased only blood pressure (BP) significantly, and decreased left ventricular pressure ( LVP ) temporarily. At the dose of 18 mg/kg, L-THP lowered the BP, LVP, ± ( dP/dt ) max, ( dP/dt ) P-1 and HR. But the degrees o?diminutions of BP were greater than that of cardiac contractility. The inhibitory percentage of L-THP on DAP was greater than that of SAP. In addition, the extent of decrease of DAP was shown dose dependently. The results suggest that L-THP reduces the peripheral vessel resistance, and it inhibits the cardiac contractibility in high dosage.

关 键 词：四氢巴马洒 L-THP 血流动力学 

分 类 号：R965.2[医药卫生—药理学]