3％氯化钠溶液雾化吸入治疗婴幼儿毛细支气管炎的疗效观察  

Effect of nebulized hypertonic saline solution for bronchiolitis in infant

作　　者：杨善浦 刘红艳[1] 吴月超 林爱琳[3] 董虹[2] 黄爱萍[1] 张林桃[1] 潘斌[1] 王晓斌[1] Yang SP Liu HY Wu YC Huang AP Zhang LT Pan B Wang XB Dong H Lin AL(Department of Pediatrics, the People ＇s Hospital of Yuhuan County, Zhejiang 317600, China Department of Clinical Laboratory,the Peoples Hospital of Yuhuan County, Zhejiang 317600, China Department of Pediatrics, Taizhou Municipal Hospital, Taizhou , Zhejiang 318000, China)

机构地区：[1]浙江省玉环县人民医院儿科,317600 [2]浙江省玉环县人民医院检验科,317600 [3]台州市立医院儿科,浙江省台州318000

出　　处：《中国基层医药》2017年第21期3229-3232,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察3％氯化钠溶液雾化吸入治疗婴幼儿毛细支气管炎的临床疗效和安全性。方法收集2014年1月至2016年1月确诊为毛细支气管炎的95例年龄为3-13个月的患儿，按照简单随机化方法分为三组，在常规对症支持治疗的基础上，观察组A吸入3％氯化钠溶液；观察组B吸入3％氯化钠溶液加沙丁胺醇雾化溶液；对照组C吸入0．9％氯化钠溶液加沙丁胺醇雾化溶液。各组均采用氧气驱动射流雾化器雾化吸入，每6小时1次，直至出院。比较各组患儿治疗后Lowell评分、临床症状与体征缓解时间、住院时间及不良反应发生率的差异。结果治疗后三组临床症状、体征均改善。A组和B组患儿治疗后24h、48h、72hLowell评分均显著低于C组[（5．81±1．53）分、（5．85±1．37）分比（6．61士1．54）分，（4．75±1．34）分、（4．72±1．30）分比（5．52±1．29）分，（3．19±1．15）分、（3．22±1．16）分比（3．90士1．01）分，z=-1．999、-2．241、-2．518和-2．002、-2．335、-2．316，均P〈0．05）]；A组和B组的咳嗽、气促和肺部哕音消失时间和平均住院时间均显著短于c组[（6．63±1．41）d、（6．56±1．37）d比（7．35．4-1．25）d，（5．19±1．03）d、（5．25±1．05）d比（5．87±1．09）d，（5．75±1．34）d、（5．72±1．51）d比（6．68±1．60）d，（7．25±1．37）d、（7．16±1．48）d比（8．10±1．47）d，z=-2．498、-2．469、-2．359、-2．213和-2．982、-2．405、-2．373、-2．222，P〈0．05。或P〈0．01]；而A组与B组在治疗后Lowell分差、临床改善效果及平均住院时间差异均无统计学意义[（5．81±1．53）比（5．85±1．37），（4．75±1．34）比（4．72±1．30），（3．19±1．15）比（3．22±1．16），（6．63±1．41）d比（6．56±1．37）d，（5．19±1．03）d比（5．25±1．05）d，（5．75±1．34）d比（5．72±1．51）d，（7．25±1．37�Objective To assess the efficacy and safety of nebulized hypertonic saline solution in infant with bronchiolitis. Methods From January 2014 to January 2016,95 patients at 3 - 13 months old in our hospital who diagnosed as bronchiolitis were randomly divided into three groups. On the basis of conventional suit support treatment, the observation group A was given nebulized 3% hypertonic saline （ n = 32）, the observation group B was given nebulized 3% hypertonic saline and salbutamol （n = 32）, and the control group C was given nebulized normal saline （0.9%） and salbutamol （n =31 ） ,this therapy was repeated every 6 hours until discharge. The Lowell score,clinical symptoms remission time, days of hospitalization and incidence rate of adverse reaction of the three groups were compared. Results After treatment, the symptoms and signs of the three groups were all improved. The Lowell scoreswere lower in the two observation groups compared to the control group C in 24,48,72 hours after treatment[ （5.81± 1.53） points and （5.85 ± 1.37） points vs. （6.61 ±1.54） points, （4.75± 1.34） points and （4.72 ± 1.30） points vs. （5.52 ± 1.29） points, （3.19 ± 1.15 ） points and （3.22 ± 1.16） points vs. （3.90 ± 1.01 ） points, Z = - 1. 999, - 2. 241, - 2. 518 and - 2. 002, - 2. 335, - 2. 316, all P 〈 0.05 ）. And the cough, wheezing remission time and pulmonary rales disappearance time, days of hospitalization in the two observation groups were also shorter, there were statistically significant differences [ （6.63 ± 1.41 ） d and （6.56 ± 1.37 ） d vs. （7.35 ± 1.25 ） d, （ 5.19 ± 1.03 ） d and （5.25 ±1.05）d vs. （5.87 ＋ 1.09）d,（5.75 ±1.34）d and （5.72 ± 1.51）d vs. （6.68 ± 1.60）d, （7.25 ±1.37）d and （7.16＋1.48）d vs. （8.10 ±1.47）d,Z= -2.498, -2.469, -2.359, -2.213 and -2.982, -2.405, -2. 373, -2. 222 ,P 〈 0.05 ,or P 〈 0.01 ）]. There were no significant differences in the Lowell score, the length of time of cough, wheeze,

关 键 词：毛细支气管炎 氯化钠 雾化吸入 

分 类 号：R725.6[医药卫生—儿科]