阿莫西林克拉维酸钾、头孢噻肟单用与联用治疗新生儿肺炎的疗效及对肠道微生态的影响  

Efficacy of amoxicillin, clavulanate potassium and cefotaxime in the treatment of neonatal pneumonia and its influence on intestinal microflora

作　　者：邹昌文[1] 胥亚福 Zou CW Yu YF(Department of Pharmacy,the People＇s Hospital of Sichuan Tibetan and Qiang Autonomous Prefecture,Aba Prefecture, Sichuan 624000,China Department of Paediatrics, the People＇s Hospital of Sichuan Tibetan and Qiang Autonomous Prefecture ,Aba Prefecture, Sichuan 624000, China)

机构地区：[1]阿坝藏族羌族自治州人民医院药剂科,四川省阿坝624000 [2]阿坝藏族羌族自治州人民医院儿科,四川省阿坝624000

出　　处：《中国基层医药》2017年第21期3270-3273,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨阿莫西林克拉维酸钾、头孢噻肟单用与联用治疗新生儿肺炎的疗效及对肠道微生态的影响。方法选取2014年6月至2016年6月阿坝州藏族羌族自治州人民医院诊治的310例新生儿肺炎为研究对象，根据随机数字表法分为三组，A组100例，采用阿莫西林克拉维酸钾，B组105例，采用头孢噻肟治疗，C组105例，阿莫西林克拉维酸钾联合头孢噻肟治疗，比较三组治疗效果及肠道微生态的差异。结果三组治愈时间[（5．2±1．3）d比（5．4±1．5）d比（5．3±1．4）d]差异均无统计学意义（均P〉0．05）。A组、B组、C组及对照组间比较，肠道微生态差异均有统计学意义（F=11．741、7．066、6．163、8．752、22．851，均P〈0．05）。且A组、B组、C组乳酸杆菌、双歧杆菌、肠球菌、真杆菌均显著少于对照组，C组显著少于A组及B组，差异均有统计学意义（t=10．453、6．843、5．974、17．654，均P〈0．05）。A组、B组、C组肠杆菌显著多于对照组，C组肠杆菌显著多于A组、B组，差异均有统计学意义（t=6．574、4．634、3．968、9．893，均P〈0．05）。结论在新生儿肺炎的治疗中，阿莫西林克拉维酸钾、头孢噻肟单用与联用疗效相当，但联合用药对肠道微生态影响大。Objective To investigate the efficacy of amoxicillin,clavulanate potassium and cefotaxime in the treatment of neonatal pneumonia and its influence on intestinal microflora. Methods 310 cases of neonatal pneumonia diagnosed in the hospital from June 2014 to June 2016 were selected as the subjects. They were divided into three groups according to random number table. The group A （100 cases） was treated with amoxicillin and clavulanate potassium,group B（ 105 cases） was treated with cefotaxime, group C （105 cases） was treated with amoxicillin, clavulanate potassium and cefotaxime. The effect and the difference of intestinal microecology were compared among the three groups. Results There were no statistically significant differences among the three groups in effect and the cure time [ （ 5.2 ± 1.3 ） d vs. （5.4 ± 1.5 ） d vs. （ 5.3 ± 1.4 ） d ] （ P 〉 0.05 ）. There were statistically significant differences in intestinal microecology among the group A, group B, group C and control group （x2 = 11. 741,7. 066,6. 163,8. 752, 22. 851, all P 〈 0.05 ）. The lactobacillus, Bifidohacterium, Enterococcus and true Bacillus of group A, group B, group C were less than those of the control group,which in group C were significantly less than group A and group B,there were statistically significant differences （t = 10.453,6. 843,5. 974,17. 654, all P 〈 0.05 ）. The Enterohacteriaceae of group A,group B and group C was significantly more than that of the control group, and the Enterobacteriaceae of group C was significantly more than that in group A and group B, there were statistically significant differences （ t = 6. 574,4.634,3. 968,9. 893, all P 〈 0.05 ）. Conclusion Amoxicillin, clavulanate potassium and cefotaxime are effective in the treatment of neonatal pneumonia,the combined use of drugs has great influence on intestinal microflora.

关 键 词：肺炎 阿莫西林克拉维酸钾 头孢噻肟 肠道微生态 婴儿 新生 

分 类 号：R722.135[医药卫生—儿科]