消癌平注射液与胰岛素在葡萄糖注射液中的配伍稳定性考察  

Compatible Stability of Xiaoaiping Injection and Insulin in Glucose Infusion

作　　者：彭雯[1] 王耀华 贾聚坤[1] 孙志强 孙冬晓 孟岩[1] 任晓华[1] Peng Wen Wang Yaohua Jia Jukun Sun Zhiqiang Sun Dongxiao Meng Yan Ren Xiaohua(The First Hospital of Shijiazhuang, Shijiazhuang 050011, China Affiliated Hospital of Hebei Medical University)

机构地区：[1]石家庄市第一医院,石家庄050011 [2]河北医科大学附属医院

出　　处：《中国药师》2017年第9期1665-1667,共3页China Pharmacist

基　　金：石家庄市科学技术研究与发展支撑计划项目(编号:151460803)

摘　　要：目的:考察消癌平注射液与胰岛素在葡萄糖注射液中的配伍稳定性。方法:观察室温下24h内消癌平注射液与胰岛素在葡萄糖注射液中配伍后溶液外观、不溶性微粒、pH的变化,以及配伍液中绿原酸和胰岛素的含量变化。结果:配伍液在室温24h内性质稳定、外观、pH无明显变化,无气体沉淀产生、不溶性微粒12h内无明显变化,但24h不溶性微粒数明显升高。主要成分绿原酸及胰岛素的含量均无明显变化。结论:在该试验条件下,12h内消癌平注射液与胰岛素在5%葡萄糖注射液中配伍稳定。Objective： To observe the compatibility of Xiaoaiping injection and insulin for injection in glucose infusion. Methods： The changes in appearance, particles and pH of the mixture in 24h at ambient temperature were observed. The concentration of chlorogenic acid and insulin were determined by HPLC. Results： There were no obvious changes in appearance, pH, precipitation or turbidity generation, and the contents of insulin and chlorogenic acid kept stable in 12 h. The number of insoluble particles was stable in 12 h, and then gradually increased in 24 h. Conclusion： Xiaoaiping injection and insulin in 5% glucose infusion is stable in 12h under the testing conditions.

关 键 词：消癌平注射液 胰岛素 稳定性 配伍 

分 类 号：R942[医药卫生—药剂学]