肝郁脾虚型功能性消化不良代谢组学研究  

Metabonomics research of functional dysplasia of hepatic stagnation and spleen deficiency type

作　　者：新昕[1,2] 林卉[1] 任路[1] Xin Xin Hui Lin Lu Ren(Liaoning Traditional Chinese Medicine University, Shenyang 110847, Liaoning Province, China Shenyang Mental Health Center, Shenyang 110168, Liaoning Province, Chin)

机构地区：[1]辽宁中医药大学,辽宁省沈阳市110847 [2]沈阳市精神卫生中心,辽宁省沈阳市110168

出　　处：《世界华人消化杂志》2017年第29期2591-2596,共6页World Chinese Journal of Digestology

基　　金：辽宁特聘教授项目~~

摘　　要：功能性消化不良(functional dyspepsia,FD)是一种常见的与精神情志因素相关的消化系统疾病,现代医学认为FD发病机制与"脑-肠轴"对消化系统影响关系密切,但尚缺乏客观生物标志物的诊断与评估方法.近年来,应用代谢组学观察代谢产物的病理改变研究本病已成为热点,其为FD的诊断和治疗提供了方向性指导.中医学认为"肝郁脾虚"是FD的主要病因,代谢组学的方法符合中医学整体观念及辨证论治的原则,可以用来研究"生理-心理-社会"多重病因对机体的影响.目前,通过分析代谢产物改变的方法,应用中医疗法探究本病的致病与康复的机制取得了较好进展,现予以综述.Functional dyspepsia （FD） is a common digestive disease that is associated with many psychological factors. Modern medicine considers that the pathogenesis of FD is closely related to the effects of the brain-gut axis on the digestive system, but there is still a lack of objective biomarkers for the diagnosis and evaluation of this disease. In recent years, the application of metabonomics to study the pathological changes of metabolites has become a hot spot. Traditional Chinese medicine considered that hepatic stagnation and spleen deficiency is largely responsible for the pathogenesis of FD. The metabonomics study of FD coincides with the concept of holisms and the principle of treatment based on syndrome differentiation in TCM. Nowadays, great progress has been made in the intervention of metabolites changes by acupuncture, Chinese herbal medicine and other methods. This paper will review the recent progress in the metabonomics research of functional dysplasia of hepatic stagnation and spleen deficiency type.

关 键 词：功能性消化不良 肝郁脾虚 代谢组学 

分 类 号：R259[医药卫生—中西医结合]