低出生体质量儿追赶性生长对健康的影响  

Health impact of catch-up growth in low-birth weight infants:a systematic review

作　　者：门光国[1] 王丽丽 王凤敏[1] 崔英波[1] MEN Guangguo WANG Lili WANG Fengmin et al.(Department of Neonatology, Ningbo Women and Children＇s Hospital, Ningbo 315012, China)

机构地区：[1]宁波市妇女儿童医院新生儿科,315012 [2]山东省东阿县人民医院儿科

出　　处：《浙江医学》2017年第17期1449-1454,共6页Zhejiang Medical Journal

摘　　要：目的本研究旨在系统地审查和评价低出生体质量儿(LBWI)追赶性生长对近期和长期健康的影响。方法检索MEDLINE、EMBASE、万方数据和中国知网,使用偏倚风险评估工具来评估文献质量,并使用GRADE评估证据质量。结果 7项研究符合纳入标准。在关于近期健康结局的5项研究中,3项发现在体质量追赶性生长和体质量和/或葡萄糖代谢之间存在正相关;1项显示降低了住院风险。关于远期健康结局的3项研究发现追赶性生长与较高的体质量、BMI或胆固醇水平相关。GRADE评价表明证据的数量和质量低。结论 LBWI出生后的追赶性生长对近期健康有益,对远期健康可能有不利影响,但证据有限。Objective To systematically review the short-term and long-term health consequences of catch-up growth in low birth weight infants （LBWI）.Methods The databases of MEDLINE,EMBASE,Wanfang data and CNKI were searched for studies on the health impact of catch-up growth in LBWI.The quality of studies was assessed using the risk of bias assessment tool,and the power of evidence was assessed using the GRADE tool.Results Seven studies met the inclusion criteria for health outcomes of catch-up growth.Positive associations between weight catch-up growth and body mass and/or glucose metabolism were revealed in 3 out of 5 studies on short-term health outcomes,while the reduced risk of hospitalisation was suggested in one study.The association between catch-up growth and higher BMI or cholesterol was found in 3 studies on longer-term health outcomes.GRADE assessment suggested that the quantity and quality of evidence were low.Conclusion Catch-up growth following LBWI has short-term health benefits,but may have adverse long-term health impacts,but the evidence is relatively weak.

关 键 词：追赶性生长 低出生体质量儿 结局 

分 类 号：R722.6[医药卫生—儿科]