维生素E防治早产儿支气管肺发育不良临床效果观察  

Clinical effect of vitamin E for prevention and treatment of bronchopulmonary dysplasia in prematures

作　　者：惠婷婷 齐戈尧 王君霞[1] 戴永利[1] 罗德春[1] 郭林梅[1] 杨玲玲[3] HUI Tingting QI Geyao WANG Junxia et al(Department of Pediatrics, PLA Lanzhou Command General Hospital, Lanzhou 730050, Chin)

机构地区：[1]兰州军区兰州总医院儿科,730050 [2]兰州军区兰州总医院陆军后勤训练基地卫生队,730050 [3]兰州军区兰州总医院ICU,730050

出　　处：《浙江医学》2017年第18期1570-1572,1580,共4页Zhejiang Medical Journal

摘　　要：目的观察维生素E防治早产儿支气管肺发育不良(BPD)的临床效果。方法 (1)选择符合标准的早产儿80例,按照简单随机抽样法分为维生素E预防组和对照预防组各40例,并比较两组BPD发病情况。(2)选择符合轻度BPD诊断标准的患儿30例,按照简单随机抽样法分为维生素E组、肺泡表面活性物质(PS)组和对照组各10例。(3)选择符合中度BPD诊断标准的患儿60例,按照(2)中所述方法同样分为3组,每组20例。分别比较轻度和中度BPD 3组患儿呼吸窘迫和低氧血症发生率和发生次数,并比较中度BPD 3组患儿高碳酸血症发生率。(4)用药方法:维生素E预防BPD:维生素E,2.5mg/kg,口服1次/d;维生素E治疗BPD:维生素E,5mg/kg,口服1次/d;PS组:猪肺磷脂注射液,150mg/kg,气管内滴注。结果维生素E预防组BPD发病率和发病程度均轻于对照预防组,差异均有统计学意义(均P<0.05)。3组轻度BPD患儿呼吸窘迫和低氧血症发生率及平均每例患儿发生次数比较差异均无统计学意义(均P>0.05)。3组中度BPD患儿呼吸窘迫和低氧血症发生率及平均每例患儿发生次数比较差异均有统计学意义(均P<0.05)。两两比较发现,维生素E组与PS组、对照组呼吸窘迫发生率比较差异均无统计学意义(均P>0.05)。而维生素E组和PS组低氧血症发生率、呼吸窘迫及低氧血症平均每例患儿发生次数比较差异均有统计学意义(均P<0.05),但与对照组比较差异均无统计学意义(均P>0.05)。PS组高碳酸血症发生率明显低于其他两组,差异均有统计学意义(均P<0.05)。结论维生素E对早产儿BPD发生具有一定的预防作用,但用于治疗BPD并无明显效果。Objective To evaluate the clinical effect of vitamin E for prevention and treatment of bronchopulmonary dysplasia（BPD） in premature infants. Methods Eighty prematures were divided into vitamin E group and control group by simple sampling. Oral vitamin E 2.5mg/kg q.d was given to vitamin E group and placebo was given to control group, the incidence of BPD was compared between two groups. Thirty prematures with mild BPD and sixty prematures with moderate BPD were randomly assigned in three groups： vitamin E, pig lung phospholipid 150mg/kg by endotracheal drip and placebo were given to vitamin E group, PS group and control group, respectively. The frequency of respiratory distress and hypoxemia was compared among three groups. Results The incidence and degree of BPD in vitamin E group were lower than that in control group （both P〈0,05）. The frequency of BPD in PS group was lower than that in vitamin E and control group, both for prematures with mild BPD or moderate BPD （all P〈0.05）, and there was no significant difference in frequency of BPD between vitamin E and control groups （P 〉0.05）. The frequency of hypercapnia in PS group of prematures with medium BPD was lower than other two groups （both P〈 0.05）. Conclusion Vitamin E can prevent BPD in prematures to some extent, but it may have no effect in treatment of BPD.

关 键 词：维生素E 支气管肺发育不良 早产儿 临床效果 

分 类 号：R722.6[医药卫生—儿科]