芪参益气滴丸联合薯蓣皂苷片治疗冠心病心绞痛的临床研究  

Clinical study on Qishen Yiqi Dropping Pills combined with Discornin Tablets in treatment of angina pectoris of coronary heart disease

作　　者：薛玉刚 王翅遥 尚福军 程锦 XUE Yu-gang WANG Chi-yao SHANG Fu-jun CHEN Jin(Department of Cardiology, the Second Affiliated Hospital of the Fourth Military Medical University, Xi＇an 710038, China)

机构地区：[1]中国人民解放军第四军医大学第二附属医院心脏内科,陕西西安710038

出　　处：《现代药物与临床》2017年第10期1832-1835,共4页Drugs & Clinic

摘　　要：目的探讨芪参益气滴丸联合薯蓣皂苷片治疗冠心病心绞痛的临床疗效。方法选取2016年2月—2017年2月在中国人民解放军第四军医大学第二附属医院进行治疗104例冠心病心绞痛患者为研究对象,依据用药的差别分为对照组(52例)和治疗组(52例),对照组口服薯蓣皂苷片,160 mg/次,2次/d。治疗组在对照组基础上口服芪参益气滴丸,0.5 g/次,3次/d。两组患者均治疗2周。评价两组患儿临床疗效,同时比较治疗前后两组患儿心电图疗效、心绞痛发作次数和持续时间、血清学指标和心功能指标。结果治疗后,对照组患者的总有效率为80.77%,显著低于治疗组的96.15%,两组比较差异具有统计学意义(P<0.05)。治疗后,对照组和治疗组患者心电图疗效分别为69.23%、90.38%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者心绞痛发作次数和持续时间均显著减少(P<0.05);且治疗组患者心绞痛发作次数和持续时间比对照组更少(P<0.05)。治疗后,两组患者血清白细胞介素-1β(IL-1β)、IL-18、妊娠相关血浆蛋白A(PAPP-A)、核转录因子-κB(NF-κB)水平均明显下降(P<0.05);且治疗组上述血清学指标显著低于对照组(P<0.05)。治疗后,两组患者左心室射血分数(LVEF)和心排血量(CO)显著增高,左室收缩末内径(LVESD)显著缩短,同组比较差异具有统计学意义(P<0.05);且治疗组患者上述指标比对照组改善更明显(P<0.05)。结论芪参益气滴丸联合薯蓣皂苷片治疗冠心病心绞痛可有效减少心绞痛发作次数,降低机体炎症反应和改善心功能,具有一定的临床推广应用价值。Objective To investigate the clinical efficacy of Qishen Yiqi Dropping Pills combined with Discornin Tablets in treatment of angina pectoris of coronary heart disease. Methods Patients （104 cases） with angina pectoris of coronary heart disease in the Second Affiliated Hospital of the Fourth Military Medical University from February 2016 to February 2017 were divided into control （52 cases） and treatment（52 cases）groups according to different treatments.Patients in the control group were po administered with Discornin Tablets,160 mg/time,twice daily.Patients in the treatment group were po administered with Qishen Yiqi Dropping Pills on the basis of the control group, 0.5 g/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the ECG curative effect, the frequency and duration of angina pectoris, serological indexes and cardiac function indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.77%, which was significantly lower than 96.15% in the treatment group, and the difference was statistically significant between two groups （P 〈 0.05）. After treatment, the ECG curative effect in the control and treatment groups were 69.23% and 90.38%, respectively, and there were differences between two groups （P 〈 0.05）. After treatment, the frequency and duration of angina pectoris in two groups were significantly decreased （P 〈 0.05）. And the frequency and duration of angina pectoris in the treatment group was significantly less than those in the control group （P 〈 0.05）. After treatment, the serum IL-1β, IL-18, PAPP-A and NF-κB level in two groups was significantly decreased （P 〈 0.05）. And the serological indexes in the treatment group were significantly lower than those in the control group （P 〈 0.05）. After treatment, the LVEF and CO in two groups was significantly increased, but LVESD was significantly decreased

关 键 词：薯蓣皂苷片 芪参益气滴丸 冠心病 心绞痛 妊娠相关血浆蛋白 左室收缩末内径 

分 类 号：R972[医药卫生—药品]