基于1,3-偶极环加成的新型螺[吲唑-异噁唑]衍生物合成及表征  

Synthesis and Characterization of Novel Spiro[Indazole-Isoxazol] Derivatives via 1,3-Dipolar Cycloaddition

作　　者：刘秋华[1] 旷国强 唐子龙[1] LIU Qiu-hua KUA NG Guo-qiang TANG Zi-long(School of Chemistry and Chemical Engineering, Key Laboratory of Theoretical Organic Chemistry and Function Molecule of Ministry of Education, and Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, Hunan University of Science and Technology, Xiangtan 411201, China)

机构地区：[1]湖南科技大学化学化工学院理论有机化学与功能分子教育部重点实验室精细聚合物可控制备及功能化应用湖南省重点实验室,湖南湘潭411201

出　　处：《精细化工中间体》2017年第4期18-24,共7页Fine Chemical Intermediates

基　　金：国家自然科学基金青年项目(21602054)

摘　　要：以1-苯基-6,7-二氢-1H-吲唑-4(5H)-酮和取代芳香醛为原料,在碱性条件下缩合得到5-芳亚甲基-1-苯基-6,7-二氢-1H-吲唑-4(5H)-酮,再与腈氧化物进行1,3-偶极环加成得到系列4'-(4-芳基)-3'-(2,6-二氯苯基)-1-苯基-6,7-二氢-4'H-螺[吲唑-5,5'-异噁唑]-4(1H)-酮新化合物,采用NMR、IR、MS以及元素分析表征其结构。The condensation of 1-phenyl-6,7-dihydro-lH-indazol-4 （5H）-one and substituted aromatic aldehyde yielded 5-arylmethylene-l-phenyl-6,7-dihydro-lH-indazol-4 （5H）-one under alkaline condition. The 1,3-dipolar cyeloaddition of nitrile oxide to these materials acquired above afforded a series of novel 4＇-（4-aryl）-3＇-（2,6- dichlorophenyl）-1-phenyl-6,7-dihy-dro-4＇H-spiro[indazole-5,5＇-isoxa-zol]-4（1H）-ones. The structures of all the products were characterized by NMR, IR, MS together with elemental analysis.

关 键 词：螺杂环 1 3-偶极环加成 腈氧化物 异噁唑 

分 类 号：O626.2[理学—有机化学]