雾霾暴露对气道炎症因子表达的影响  

Effects of haze exposure on airway inflammation factor expression

作　　者：任雪珠[1] 阎锡新[1] 关继涛[1] 张会然[1] 龚志晶 许圣慧 邸沂遥 施晓娟[1] 陈国强 Ren Xuezhu Yan Xixin Guan Jitao Zhang Huiran Gong Zhijing Xu Shenghui Di Yiyao Shi Xiaojuan Chen Guoqiang(The First Department of Respiratory Medicine, the Second Hospital of Hebei Medical University, Hebei Institute of Respiratory Diseases, Shijiazhuang 050000, Chin)

机构地区：[1]河北医科大学第二医院呼吸一科、河北省呼吸疾病研究所,石家庄050000

出　　处：《国际呼吸杂志》2017年第20期1526-1531,共6页International Journal of Respiration

摘　　要：目的对石家庄市区中重度雾霾天气进行污染特征的分析，并探讨中重度雾霾天气短期暴露对痰液中相关炎症因子水平及细胞分类计数的影响。方法选择石家庄市中心城区户外工作人群为研究对象，分别于岗前、岗后（间隔4～6h）收集痰液送炎症因子检测、细胞计数，分析其前后统计学差异。结果①冬季石家庄市区雾霾严重，颗粒物、硫化物、氮氧化物都比较严重；3～4月份有所改善，细颗粒物及有害气体改善显著，但是由于沙尘影响可吸入颗粒物比例还是比较大；5～7月人夏季节均有明显改善，颗粒物及有害气体水平都有显著降低。②雾霾短期暴露后痰液中促炎因子IL2、IL-8表达升高，抑炎因子转化生长因子β1（TGF-β1）表达降低，脂质过氧化产物丙二醛（MDA）、超氧自由基清除因子超氧化物歧化酶3（SOD3）表达水平降低，差异有统计学意义。③雾霾短期暴露后痰液中中性粒细胞及淋巴细胞数目较暴露前增多趋势，但差异无统计学意义。结论雾霾对户外高暴露人群存在一定健康威胁，可以刺激气道产生一定的炎症反应，对机体防御功能及氧化应激能力造成干扰及影响。Objective To analyze the characteristics of Shijiazhuang severe air pollution and study the effects of short term haze exposure on sputum inflammatory factors and cell counts. Methods Outdoor workingcrowds in Shijiazhuang city were selected as the research object, sputum was collected before and after work （4-6 hour intervals） for inflammatory factors detection and cell counting. The significant difference was also analyzed. Results （1）In winter, the haze in the urban area of Shijiazhuang was serious, with high concentration of particulate matters, sulfide and nitrogen oxides; In March and April, the concentration of fine particulate matters and harmful gases were improved significantly. However, the proportion of inhalable particles was still relatively large. And then, the air pollution was obviously improved from May to July. the concentration of particles and harmful gases were also reduced dramatically. （2）The content of the pro inflammatory factor interleukin 2 （IL-2） and IL-8 were significantly increased in sputum after haze exposure, inhibiting inflammatory factor transforming growth factor β1 （TGF-β1） was decreased, and the expression level of the lipid per-oxidation product malondia- ldehyde （MDA） and superoxide radical scavenging factor superoxide dismutase-3 （SOD3） were decreased obviously. （3）The number of the neutrophilsand lymphocytes increased after exposure, but there were no significant differences. Conclusions Haze exposure has health threats among the outdoor working crowd, which could induce the airway inflammatory response and affect the body defense capability and oxidative stress function.

关 键 词：颗粒物 暴露 炎症 细胞学 

分 类 号：R56[医药卫生—呼吸系统] X513[医药卫生—内科学]