胃复安对豚鼠心肌生理特性及犬血液动力学的作用  

EFFECTS OF METOCLOPRAMIDE ON PHYSIOLOGIC PROPERTIES OF GUINEA PIG PAPILLARY MUSCLES AND HEMODYNAMICS IN DOGS

作　　者：卢晓东[1] 赵东科[2] 赵更生[2] 高小利[2] 李孝光[2] 

机构地区：[1]山西医学院药理教研室,太原030001 [2]西安医科大学药理教研室,710061

出　　处：《中国药理学通报》1991年第3期210-213,共4页Chinese Pharmacological Bulletin

摘　　要：胃复安(MCP)30～100μmol/L能抑制豚鼠心室乳头状肌收缩力和肾上腺素诱发的自律性,降低兴奋性,延长功能不应期。此外,对豚鼠右心房收缩力和自律性有抑制作用。麻醉开胸犬iv MCP5mg/kg立即出现HR减慢,SBP,DBP,MAP,LVSP,CI,dP/dt_(max)和TPR增加;iv 10mg/kg MCP后,除CI仍增加外,上述各参数均降低;ivMCP5～10mg/kg对V_((?)e)～+dP/dt_(max)和T值无显著影响。The effects of metoclopramide( MCP ) on the physiologic properties of guinea pig papillary muscles and the hemodynamics in anesthetic dogs were studied. MCP decreased contractility, increased the epinephrine concentration inducing automaticity and shifted the voltage-time plot to the right. But the functional refractory period was prolonged. Furthermore, the contractility and automaticity of the right auricle were decreased. MCP 5 mg/kg iv increased cardiac index (CI), systolic blood pressure ( SBP ), diastolic blood pressure ( DBP ), left ventricular systolic pressure ( LVSP ), maximal rate of change of intraventricular pressure ( dP/dtmax ), and total peripheral resistance ( TPR ) while MCP 10mg/kg iv decreased SBP, DBP, LVSP, dP/dtmax and TPR except increase of CI.

关 键 词：胃复安 乳头状肌 收缩性 

分 类 号：R965.2[医药卫生—药理学]