健脾益肾排毒法治疗慢性肾功能衰竭的Meta分析  

Meta Analysis of Treatment of Chronic Renal Failure by Strengthening Spleen and Tonifying Kidney

作　　者：冯雪[1] 高智[1] FENG Xue GAO Zhi(Wuhan City TCM Hospital, Wuhan, Hubei, China,430014)

机构地区：[1]武汉市中医医院,湖北武汉430014

出　　处：《河南中医》2017年第10期1774-1779,共6页Henan Traditional Chinese Medicine

基　　金：武汉市卫生和计划生育委员会临床医学科研项目(编号:WZ11D13)

摘　　要：目的:通过系统评价的方法,分析健脾益肾排毒法治疗慢性肾功能衰竭的疗效,找出目前慢性肾功能衰竭临床试验中存在问题,并为临床上制定治疗慢性肾功能衰竭的有效方案提供强有力的证据。方法:运用系统评价方法对数据库开库以来至2016年以健脾益肾排毒法治疗慢性肾功能衰竭的临床文献进行收集和分析,对符合标准的文献提取数据信息。然后采用Revman5.3进行Meta分析,得出结论。结果:通过Meta分析研究11篇临床文献表明,在应用西医常规治疗基础上联合健脾益肾排毒法的治疗方法相较于单纯用西医常规治疗,可以提高慢性肾功能衰竭患者的临床疗效,有效降低血肌酐(serum creatinine,Scr)、血尿素氮(blood urea nitrogen,BUN),提高内生肌酐清除率(creatinine clearance rate,Ccr)、肾小球滤过率(glomerular filtration rate,GFR)、血红蛋白(hemoglobin,HGB),改善临床症状。11篇文献仅1篇指出未出现明显不良反应,余文献并未说明是否存在不良反应。结论:在西医常规方法基础上加用健脾益肾排毒法治疗慢性肾功能衰竭与单独使用西医基础治疗结果比较,观察组疗效较对照组好,但因筛选出的文献质量相对偏低,还有着较大的偏倚,故应进一步展开样本量大的、随机的、多中心的临床研究。Objective： To analyze the clinical curative effect of detoxification method by strengthening spleen and tonifying kidney on chronic renal failure through the systematic evaluation,find out the existing problems in the clinical trials of chronic renal failure,and provide strong evidence for drawing up effective scheme to treat chronic renal failure in clinical practice. Methods： Using the method of systematic evaluation,the clinical literature of database from the beginning until 2016 on chronic renal failure treated by invigorating spleen and kidney detoxification method was collected and analyzed,and the literature in accordance with the criterions were extracted. Then they were given meta analysis by using Revman5. 3 to draw conclusions. Results： The meta analysis of 11 clinical literatures showed that compared with single conventional Western medicine treatment,detoxification method by strengthening spleen and tonifying kidney combined with conventional Western medicine could improve the clinical efficacy in patients with chronic renal failure,reduce serum creatinine（ Scr）,and blood urea nitrogen（ BUN）,imcrease Creatinine clearance rate（ Ccr）,Glomerular filtration rate（ GFR）,and hemoglobin（ HGB）,and improve the clinical symptoms. Only one of the 11 articles indicated no obvious adverse effects,and the rest terature did not indicate any adverse effects. Conclusion： The clinical curative effect of Detoxification method by strengthening spleen and tonifying kidney based on single conventional Western medicine in the observation group is better than that of the control group. However,because the quality of the selected literature is relatively low,there is a big bias,so it is necessary to develop a large,randomized,multicenter clinical study.

关 键 词：健脾益肾排毒法 慢性肾功能衰竭 中西医结合治疗 随机对照试验 META分析 

分 类 号：R277.5[医药卫生—中医学]