酸枣仁汤辅助治疗有助于改善失眠患者的睡眠质量  

Improving Sleep Quality in Patients with Insomnia by Auxiliary Treatment with Suanzaoren Decoction

作　　者：孙伯欣[1] 李羚青[2] 

机构地区：[1]华中农业大学医院,武汉430070 [2]湖北省中医院,武汉430070

出　　处：《基因组学与应用生物学》2017年第10期4018-4022,共5页Genomics and Applied Biology

基　　金：华中农业大学校医院提供项目资助

摘　　要：为了探究酸枣仁汤对治疗失眠的药理作用,本研究将96例失眠症患者根据随机数字表分为两组,其中对照组予以艾司唑仑片治疗,观察组予以艾司唑仑片+酸枣仁汤(suanzaoren decoction,SD)治疗。对比两组治疗前后的疗效及患者匹兹堡睡眠质量指数量表(pittsburgh sleep quality index,PSQI)得分、IL-1α、IL-1ra、IL-1β水平变化,发现观察组有效率高于对照组。两组治疗后的睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、日间功能得分较治疗前降低,观察组较对照组降低明显(p<0.05)。两组治疗前的IL-1α、IL-1ra、IL-1β水平差异无统计学意义(p>0.05);治疗后的IL-1ra、IL-1β水平较治疗前提高,IL-1ra水平较治疗前降低,且观察组比对照组变化明显(p<0.05)。研究表明酸枣仁汤可改善患者睡眠质量,是治疗失眠症的有效药物。The purpose of the study was to explore the pharmacological effects of Suanzaoren Decoction on treating insomnia. In this study, 96 cases of insomnia patients were divided into two groups according to the random number table. Control group were treated by estazolam while observation group were treated by estazolam and suanzaoren decoction（SD）. After contrasting the curative effect, pittsburgh sleep quality index（PSQI score）, and changes in levels of IL-1α, IL-1 ra, IL-1β of two groups before and after treatment, we found that the effective rate of observation group was obviously higher than that of control group（p〈0.05）. The scores of sleep quality, sleep time, sleeping time, sleep efficiency, sleep disorder and daytime function after treatment were lower than those before treatment and the change of the observation group was more obvious than the control group（p〈0.05）. There were no significant differences between the two groups of IL-1α, IL-1 ra, IL-1β levels before treatment（p〉0.05）,whereas the levels of IL-1α, IL-1β after treatment were higher than those before treatment, the levels of IL-1 ra after treatment were lower than those before treatment, and the change of the observation group was more obvious than the control group（p〈0.05）. The research showed that SD was an effective drug for the treatment of insomnia which could improve sleep quality.

关 键 词：酸枣仁汤 失眠症 疗效 PSQI 

分 类 号：R256.23[医药卫生—中医内科学]