微囊藻毒素LR的基因毒性和潜在致癌性的研究进展  

Progress in the genotoxicity and potential carcinogenicity of microcystin-LR

作　　者：肖潺潺 邓伟[2] 

机构地区：[1]广西医科大学附属肿瘤医院实验研究部,广西南宁530021 [2]广西壮族自治区肿瘤防治研究所,广西南宁530021

出　　处：《现代预防医学》2017年第21期3982-3986,共5页Modern Preventive Medicine

基　　金：国家自然科学基金资助项目(81660561)

摘　　要：目的介绍微囊藻毒素LR的基因毒性和潜在致癌性的研究进展。方法以"微囊藻毒素LR"、"基因毒性"、"致癌性"等组合为检索词,以主题、全文、摘要或关键字为检索项,检索Pub Med、Web of Science、CBM、CNKI、Wan Fang Data和VIP数据库,并进行分析、归纳。结果微囊藻毒素LR对哺乳动物的基因毒性主要有4种方式:引起DNA的损伤;诱导活性氧和氮的形成;抑制DNA损伤的修复;诱导基因突变和染色体变异。结论微囊藻毒素LR具有基因毒性和潜在致癌性,需注重微囊藻毒素(Microcystins,MCs)对人群的慢性健康效应特别是促肝癌效应的研究。Objective To introduce advances in researches on genotoxicity and potential carcinogenicity of microcystin-LR.Methods Data retrieved from Pub Med,Web of Science,CBM,CNKI,Wanfang Data and VIP database was analyzed and summarized,with ＂microcystin-LR＂,＂genotoxicity＂,＂carcinogenicity＂and other combinations serving as search words and the theme,full text,abstract or keywords serving as search terms. Results There are four main ways of genotoxicity of microcystin-LR acting on mammals： DNA damage,induction of reactive oxygen and nitrogen formation,inhibition of DNA damage repair,and induction of mutagenicity and clastogenicity. Conclusion The chronic health effects of microcystins on the population,especially the effects of promoting liver cancer should be attached importance to since microcystin-LR is genotoxic and potentially carcinogenic.

关 键 词：微囊藻毒素 微蓝藻毒素LR 基因毒性 致癌 

分 类 号：R181.22[医药卫生—流行病学]