逍遥散加减对糖尿病合并抑郁症治疗作用的Meta分析  

Meta-Analysis of Xiao Yao San Treatment of Type 2 Diabetes Combined with Depression

作　　者：周珺[1] 张黎[1] 席红领 李茂星[1] 贾正平[1] 张汝学[1] 周臖 

机构地区：[1]兰州军区兰州总医院全军高原环境损伤防治重点实验室、国家中医药管理局临床中药学重点学科,甘肃兰州730050

出　　处：《中医学报》2017年第10期1878-1882,共5页Acta Chinese Medicine

基　　金：国家自然科学基金面上项目(81173620)

摘　　要：目的:系统评价逍遥散加减对糖尿病合并抑郁症患者各项指标的治疗效果。方法:利用Meta分析的方法,计算机检索CNKI、维普、万方和Pub Med数据库,并手工检索相关杂志,全面收集有关逍遥散加减治疗糖尿病合并抑郁症患者的临床研究文献,并按照文献纳入、排除标准筛选合格的独立病例对照研究。筛选文献提取资料并对文献进行质量评价,提取有效数据后,分析逍遥散加减对糖尿病合并抑郁症患者的汉密尔顿量表值、空腹血糖、糖化血红蛋白水平的影响,采用Rev Man 5.0软件进行Meta分析。结果:本研究共收集48篇文献,依据纳入标准和排除标准共纳入5个病例对照研究,其中试验组242例,对照组240例。5篇文献观察了汉密尔顿量表值,4篇文献观察了空腹血糖、糖化血红蛋白水平。Meta分析结果显示,逍遥散加减治疗可明显改善糖尿病合并抑郁症患者的汉密尔顿量表值、空腹血糖、糖化血红蛋白水平,具有很好的治疗作用,但是受纳入研究的数量和质量所限。结论:逍遥散加减可有助于改善治疗糖尿病合并抑郁症患者的病情。Objective：To systematically evaluate the clinical efficacy of Xiao Yao San in treating type 2 diabetes combined with depression. Methods ： Computer retrievals were made in CNKI, VIP, Wanfang and PubMed, Embase, Cochrane Library and relevant literature references, and manual retrievals were made for journals and conference papers, in order to collect randomized or semirandomized controlled trials concerning Xiao Yao San in treating type 2 diabetes combined with depression. The quality assessment of the included studies was evaluated,while the data was extracted, the effect of modified Xiao Yao San on Hamilton Depression Scale （HAMD） ,fasting blood glucose （FBG） and Glycated Hemoglobin （HbAlc） levels in type 2 diabetes combined with depres- sion were analyzed. RevMan 5.0 software was used for Meta-analysis. Results ： In this study, a total of 48 literatures were collected. 5 case-control studies were included according to inclusion criteria and exclusion criteria,involving 242 cases in the experimental group and 240 cases in the control group. Among those literatures ,five literatures recorded observation of HAMD,four studies re- corded assessment of FBG and HbAlc levels. The results of Meta-analysis showed that treatment with Xiao Yao San can improve the HAMD, FBG and HbAlc with statistical differences. Ahhough these results were limited because of the less number and the low quality. Conclusion：Modified Xiao Yao San can enhance the clinical efficiency on diabetic patients with depression.

关 键 词：逍遥散 糖尿病合并抑郁症 META分析 空腹血糖 糖化血红蛋白 

分 类 号：R259.872[医药卫生—中西医结合]