防己黄芪汤加减治疗小儿肾病综合征临床研究  

Clinical Study on Fangji Huangqi Decoction Treatment of Children with Nephrotic Syndrome

作　　者：曹广海 刘翠华 张小方[2] 

机构地区：[1]郑州儿童医院,河南郑州450000 [2]黄淮学院,河南驻马店463000

出　　处：《中医学报》2017年第10期2009-2012,共4页Acta Chinese Medicine

摘　　要：目的:探讨防己黄芪汤加减治疗小儿肾病综合征的临床疗效及对肾功能、凝血系统的影响。方法:收集小儿肾病综合征患儿84例,随机分为对照组和观察组,各42例,对照组患儿均予以西医常规基础治疗,观察组在对照组的基础上予以防己黄芪汤加减治疗,每日1剂,分早晚两次服用,治疗时间为12周,两组患儿以4周为1个疗程,共治疗1个疗程。治疗后,对所有患儿的临床疗效、肾功能、凝血指标及不良反应发生情况进行检测。结果:两组治疗前后相比,患儿血清尿素氮(blood urea nitrogen,BUN)、血肌酐(serum creatinine,SCr)水平降低,内生肌酐清除率(endogenous creatinine clearance rate,Ccr)水平升高,血清凝血酶原时间(prothrombin time,PT)、活化部分凝血活酶时间(activated partial thromboplastin time,APTT)水平升高,差异有统计学意义(P<0.05);与对照组相比,观察组中医证候疗效有效率较高,疾病疗效总有效率较高,血清BUN、SCr水平较低,Ccr水平较高,血清PT、APTT水平较高,差异有统计学意义(P<0.05)。两组患儿不良反应的发生率无明显差异(P>0.05)。结论:防己黄芪汤加减治疗小儿肾病综合征的临床疗效显著,能够缓解水肿症状,改善血液高凝状态,阻止肾小球微血栓形成,改善肾功能,安全性较高。Objective： To investigate the clinical efficacy of modified Fangji Huangqi decoction in treatment of nephrotic syndrome in children and its influence on renal function and blood coagulation system. Methods： 84 cases of children with nephrotic syndrome were randomly divided into the control group and the experiment group with 42 cases. The children in control group were given Western medicine therapy,the experimental group was given Fangji Huangqi decoction on the basis of the control group,1 dose daily,and taking twice. The treatment time was 12 weeks. The two groups were treated with 4 weeks for 1 course,a total of 1 course of treatment. After treatment,the clinical efficacy,renal function,coagulation index and adverse reaction were detected. Results： After treatment,compared with the treatment,the serum blood urea nitrogen（ BUN） and SCr levels of the two groups were decreased,the level of Ccr was increased,the levels of serum PT and APTT were increased,the difference was statistically significant（ P 〈0. 05）. Compared with the control group,the total effective rate of TCM syndrome in the treatment group was higher,the curative effect total efficiency was higher,the serum BUN,SCr levels were lower,levels of Ccr,serum PT and APTTr levels were higher,and the difference was statistically significant（ P〈 0. 05）. There was no significant difference in the incidence of adverse reactions between the two groups（ P〉 0. 05）. Conclusion： The clinical curative effect of Fangji Huangqi decoction treatment of children with nephrotic syndrome is significant,which can alleviate the symptoms,improve blood hypercoagulability,prevent glomerular thrombosis,improve renal function,with high safety.

关 键 词：小儿肾病综合征 防己黄芪汤 肾功能 凝血系统 

分 类 号：R259.92[医药卫生—中西医结合]