铂类抗癌药物-纳米金载药体系的研究进展  

Research Progress in Gold Nanoparticle-Based Delivery Systems of Antitumor Platinum Drugs

作　　者：刘清华[1] 杨萍 高传柱[1] 杨波[1] 钱韵旭[1] Liu Qinghua Yang Ping Gao Chuanzhu Yang Bo Qian Yunxu(Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 65050)

机构地区：[1]昆明理工大学生命科学与技术学院,昆明650500

出　　处：《化学通报》2017年第11期995-1001,共7页Chemistry

基　　金：国家自然科学基金项目(21361014;21302074)资助

摘　　要：铂类抗癌药物凭借着独特的作用机制,已成为临床治疗中应用广泛的抗癌药物之一。但由于存在较为严重的毒副作用、耐药性等问题,限制了其在临床上的使用。为了改善它的这些不足,更大限度提高药物的生物利用度并尽量减少其副作用,使用靶向给药体系改变铂类药物体内递送方式受到了广泛关注。其中铂药-纳米金载药体系因其较大的载药量、易于修饰改造、癌细胞高通透性和滞留效应、无免疫原性等显著的特点而受到研究者们的重视,本文主要介绍近十年来铂类抗癌药物-纳米金载药体系的研究进展。Platinum drugs have become one of the most widely used anticancer drugs due to their unique mechanisms of action. However,the clinical use of platinum anticancer drugs were limited by serious side effects,drug resistance and other issues. In order to overcome the deficiencies of platinum anticancer drugs,improve the bioavailability of platinum anticancer drugs and reduce their side effects,targeted drug delivery system to change the in vivo transmission method of the platinum drugs has been widely concerned. Among of them,the platinum drugsgold nanoparticles delivery system has significantly caused the attention of researchers for its high loading capacity,easy modification,cancer cells EPR effect and non-immunogenicity,etc. In this paper,the research progress in nanogold delivery systems for platinum-based antitumor drugs in recent ten years were introduced.

关 键 词：铂类药物 纳米金 载药体系 

分 类 号：TB383.1[一般工业技术—材料科学与工程] TQ460.1[化学工程—制药化工]