Pd/MIL-101的制备及非均相催化吲哚C-H活化  

Preparation of Pd/MIL-101 as a Heterogeneous Catalyst for C—H Activation of Indoles

作　　者：徐缓[1] 张茂元 黄香 史大斌[1] 

机构地区：[1]遵义医学院药学院,贵州遵义563000

出　　处：《分子催化》2017年第5期472-479,共8页Journal of Molecular Catalysis(China)

基　　金：国家自然科学基金项目(21362047);贵州省社会发展科技攻关项目(黔科合SY[2013]3061);贵州省科学技术基金项目(黔科合J字[2014]2175)资助~~

摘　　要：水热合成MIL-101,过量浸渍法吸附Pd(OAc)_2,原位还原Pd^(2+)制得Pd/MIL-101催化剂.采用XRD、XPS、SEM、ICP、HRTEM和N_2吸/脱附实验对其结构进行表征,催化剂Pd纳米粒子尺寸在1.5~2.5 nm之间,含量为1.5%.催化实验表明,Pd/MIL-101能高效催化吲哚C_2位芳基化,对于活性较差的溴代芳烃,也能得到中等以上的收率,催化剂循环5次后仍能保持较高的反应活性,发展了吲哚C_2位衍生物的简单、高效的合成方法.MIL-101 was synthesized by hydrothermal method, and Pd/MIL-101 catalyst was prepared by supporting palladium nanopartieles on metal-organic frameworks MIL-101. The microstructure and features of the catalyst were characterized by XRD, XPS, SEM, HRTEM, ICP and N2 adsorption respectively. The experimental results reveal the Pd nanoparticles on Pd/ MIL-101 range from 1.5 to 2.5 nm, and the content of Pd nanoparticles is 1.5%. The catalytic experiments show that Pd/MIL-101 has a high catalytic activity for the C2 arylation of indoles. For the poor activity of aryl bromide, the reaction has also middle yield. Moreover, the catalyst could be recycled many times. After 5 runs of catalysis, the catalyst can still maintain high reactivity. This strategy provides a simple, ef- fective method for the synthesis of indole derivatives

关 键 词：金属有机框架 PD纳米粒子 非均相催化 C-H活化 吲哚 

分 类 号：O643.3[理学—物理化学]