高强度他汀类药物治疗对冠状动脉支架内晚期管腔丢失的影响  

Effect of high intensity statin therapy on the late lumen loss of coronary stent

作　　者：赵洪磊[1] 曾繁芳[1] 陈协辉[1] 龙娟[1] 胡伟[1] 王丽丽[1] 

机构地区：[1]深圳市孙逸仙心血管医院心内科,广东深圳518112

出　　处：《岭南心血管病杂志》2017年第4期384-386,共3页South China Journal of Cardiovascular Diseases

摘　　要：目的观察阿托伐他汀对急性冠状动脉综合征患者冠状动脉支架植入术后支架内最小管腔直径的影响。方法筛选2015年2月至2016年5月在深圳市孙逸仙心血管医院接受冠状动脉支架植入术治疗的急性冠状动脉综合征患者117例,每例患者均接收规范的冠状动脉粥样硬化性心脏病(冠心病)二级预防方案治疗,行常规及阿托伐他汀20 mg/d治疗患者设为对照组(59例),行常规及阿托伐他汀40 mg/d治疗患者设为研究组(58例),记录患者冠状动脉支架植入术后即刻以及6~9个月后复查冠状动脉造影时的支架内的最小冠状动脉血管直径。结果两组均未发生心脏不良事件和再次支架植入术。其中高强度他汀组有112处病变植入了支架,对照组有91处病变植入支架,且都完成了造影随访。高强度他汀治疗组支架内晚期管腔丢失[(0.18±0.29)mm vs.(0.33±0.71)mm,P<0.0001]和节段内晚期管腔丢失[(0.17±0041)mm vs.(0.39±0.43)mm,P=0.004]与中等强度他汀治疗组比较,差异均有统计学意义。结论高强度他汀类药物可以减少冠状动脉支架术后支架内管腔直径丢失,进而预防冠状动脉内支架狭窄的发生。Objectives To observe the effect of atorvastatin on the minimal lumen diameter（MLD） of stent in patients with acute coronary syndrome after coronary stent implantation. Method From February 2015 to May 2016 in Sun Yat-sen Cardiovascular Hospital of Shenzhen , 117 patients with acute coronary artery syndrome were receiving standard scheme and stent implantation. There were 59 cases with atorvastatin 20 mg/d treatment in control group and there were 58 cases with atorvastatin of 40 mg/d in study group. MLDs of inside stent were recorded after stenting immediately and 6-9 months later. Results Cardiac adverse events and second stent implantations were not occurred in the two groups. High intensity statin therapy group had 112 lesions placed stents ,and control group had 91 stents. There were significant differences of stent late lumen loss[（0.18±0.29）mm vs.（0.33±0.71）mm,P〈0.0001]and segment late lumen loss[（0.17±0041）mm vs.（0.39±0.43）mm,P=0.004]between high intensity statin therapy group and moderate intensity statin therapy group. Conclusions High intensity statins can reduce the diameter of the inner cavity lost after coronary stenting ,then can preventing restenosis.

关 键 词：冠状动脉疾病 他汀类药物 冠状动脉造影 晚期管腔丢失 

分 类 号：R541.4[医药卫生—心血管疾病]