血清总胆红素与2型糖尿病动脉粥样硬化的相关性研究  

Relationship between serum bilirubin and carotid atherosclerosis in patients with type 2 diabetes mellitus

作　　者：李捷[1] 黄雨晴[1] 祁巧茹 钟健湖 黄橙[1] 冯颖青[1] 汤松涛 

机构地区：[1]广东省心血管病研究所心内科广东省冠心病预防重点实验室广东省人民医院(广东省医学科学院),广州510080 [2]广东省东莞市寮步镇社区卫生服务中心,广东东莞523400

出　　处：《岭南心血管病杂志》2017年第4期428-431,共4页South China Journal of Cardiovascular Diseases

基　　金：东莞市社会科技发展项目(项目编号:2013108101029;2014108101043);广州市科技计划(项目编号:2014y2-00140;项目编号:1563000381);广东省科技计划(项目编号:2014B020212008;2007B031500010)

摘　　要：目的研究血清胆红素浓度与2型糖尿病患者动脉粥样硬化的相关性。方法从社区选取2型糖尿病患者(n=57例)和健康人群(n=52名)作为研究对象,抽取入选对象空腹血液检测尿酸、血生化、肝及肾功能、血脂、空腹血糖、糖化血红蛋白和血清胆红素等指标,并完成颈动脉内膜中层厚度(intima-media thickness,IMT)的检测。根据颈动脉IMT的检测结果将入选对象分为动脉粥样硬化组40例,非动脉粥样硬化组69例。采用Spearman进行相关性分析。结果糖尿病组及健康对照组年龄、性别、血压、体质量指数、肝及肾功能、血脂浓度、血清总胆红素浓度、直接胆红素浓度和间接胆红素浓度比较,差异均无统计学意义(P>0.05)。动脉粥样硬化组血清总胆红素浓度、直接胆红素浓度和间接胆红素浓度与非动脉粥样硬化组比较,差异有统计学意义(P<0.05)。Spearman相关分析结果表明,血清总胆红素浓度(r=-0.652,P<0.001)、直接胆红素浓度(r=-0.590,P<0.001)和间接胆红素浓度(r=-0.627,P<0.001)与颈动脉IMT呈负相关。结论血清胆红素浓度与糖尿病患者颈动脉粥样硬化呈负相关。Objectives To study the relationship between serum bilirubin and carotid atherosclerosis in patients with type 2 diabetes mellitus. Methods Fifty seven patients with type 2 diabetes mellitus and 52 healthy people were selected from the community and undergone measurement of carotid intima-media thickness（IMT）. All of them were extracted the fasting blood to detect blood biochemical indicators ,hepatic and renal function ,serum lipid ,fasting blood-glucose ,glycosylated hemoglobin and serum bilirubin for analyzing. According to the results of carotid IMT measurement , they were divided into atherosclerosis group （ n=40 ） and non-atherosclerosis group （ n=69 ）. Correlation between serum bilirubin and carotid artery atherosclerosis was assessed by using the Spearman correlation coefficient. Results Age,sex,blood pressure,body mass index,fasting blood glucose,liver and kidney function, blood lipid and uric acid concentrations,serum concentrations of total bilirubin,direct bilirubin and indirect bilirubin had no significant differences between diabetes mellitus group and control group（P〈0.05）. However,serum concentrations of total bilirubin ,direct bilirubin and indirect bilirubin were significantly differences between atherosclerosis group and non-atherosclerosis group （ P〈0.05 ）. Serum concentrations of total bilirubin（r=-0.652 ,P〈0.001）,direct bilirubin （r=-0.590 ,P〈0.001） and indirect bilirubin （r=-0.627 ,P〈0.001） negatively related with carotid IMT.Conclusions Serum concentrations of bilirubin negatively with carotid atherosclerosis in patients with type 2 diabe？tes mellitus.

关 键 词：血清胆红素 2型糖尿病 颈动脉粥样硬化 

分 类 号：R543.5[医药卫生—心血管疾病] R587.1[医药卫生—内科学]