全基因组关联分析在畜禽重要经济性状中的研究进展  

Progress of Genome-wide Association Analysis on Important Economic Traits of Livestock and Poultry

作　　者：乔贤 张磊[1] 李晓凯[1] 范一星[1] 马宇浩 张燕军[1] 刘志红[1] 王瑞军[1,2] 王志英 王志新[1] 赵艳红[1] 何利兵[2] 李金泉 苏蕊[1] 

机构地区：[1]内蒙古农业大学动物科学学院、动物遗传育种与繁殖自治区重点实验室、农业部肉羊遗传育种重点实验室,内蒙古自治区山羊遗传育种工程技术研究中心,内蒙古呼和浩特010018 [2]内蒙古金莱牧业科技有限责任公司,内蒙古呼和浩特010100

出　　处：《家畜生态学报》2017年第10期1-9,共9页Journal of Domestic Animal Ecology

基　　金：国家自然科学基金项目(31660639);国家绒毛用羊现代农业产业技术体系(CARS-40-05)

摘　　要：以往通过候选基因分析和数量性状位点(quantitative trait locus,QTL)连锁分析等策略使我们对一些基因的功能有了一定了解,但是很多控制畜禽经济性状的基因还无法分离和鉴定。随着高通量测序技术的不断发展以及人类全基因组计划(human genome project,HGP)和许多动植物的全基因组测序完成,全基因组关联分析(genome-wide association study,GWAS)已经成为研究复杂性状的重要方法。文章针对GWAS在重要畜种复杂经济性状中的研究进展进行综述,梳理了近几年在动物经济性状研究中利用GWAS取得的成果,并且对GWAS研究策略与方法进行了归纳总结,旨在利用GWAS为畜禽复杂性状的遗传基础研究提供参考,同时为今后的动物育种工作奠定基础。In the past , we have been able to understand the function of some genes by candnalysis and quantitative tratt locus （QTL） linkage analysis. However , many genes controlling the economic traits of livestock and poultry can not be separated and identined. With the development of high-throughput sequencing technology , and the human genome project （HGP） and whole genome sequencing of many spe-cies has been completed , genome-wide association study （GWAS） has become an important method for the study of complex traits. This paper reviewed the genome-wide association analysis research progress oncomplex and important economic traits in livestock , and arranged the achievements made in the study ofanimal economic traits in recent years,as well as summarized the current research on GWAS methods and strategies , in order to provide a reference for the genetic basis of complex traits of livestock and poultry by GWAS , and lay the foundation for animal breeding in the future .

关 键 词：全基因组关联分析(GWAS) 畜禽 复杂性状 单核苷酸多态性(SNP) 遗传变异 

分 类 号：S811.5[农业科学—畜牧学]