一类具有C_2对称性的轴手性马来酰亚胺类化合物的合成  

Synthesis of a New Class of Chiral Maleimide Derivatives with C_2-Symmetry

作　　者：符立言 吉保明[1] 杜晨霞[2] 

机构地区：[1]洛阳师范学院化学化工学院,洛阳471022 [2]郑州大学化学与分子工程学院,郑州450001

出　　处：《有机化学》2017年第10期2685-2689,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21372112)资助项目~~

摘　　要：以廉价易得的顺丁烯二酸酐和(R)-1,1'-联二萘酚(BINOL)为起始原料,通过Williamson醚合成法、Suzuki偶联反应、脱保护基等6步反应,以6.2%~16%的总收率合成了一类具有C_2对称性的轴手性酰亚胺类化合物,并通过~1H NMR,^(13)C NMR,HRMS,IR等手段对其结构进行了表征.Starting from the readily available maleic anhydride and （R）-1,1＇-bi-2-naphthol （BINOL）, an efficient method for the synthesis of a new class of chiral maleimide derivatives with C2-symmetry was described, involving Williamson ether synthesis, Suzuki coupling reaction and deprotection reaction by microwave to give 3,4-[（R）-3,3＇-diaryl-1,1＇-binaphthyl-2,2＇-dioxy]-maleimides in 6.2%~16% yields. Moreover, the structures of the target compound and key intermediates were confirmed by 1H NMR, 13C NMR, HRMS and IR techniques.

关 键 词：酰亚胺 联萘酚 有机合成 手性 

分 类 号：O623.626[理学—有机化学]