重症急性胰腺炎肺损伤患者中的PI3K/PKB信号转导通路临床表达及意义  

Clinical Expression and Significance of P13K/PKB Signal Transduction Pathwayin Patients with Severe Acute Pancreatifis and Lung Injury

作　　者：海超 张俊志 石荷洁 Hai Chao et al(Shenzhen city people ＇s hospital （Guangdong Shenzhen 518000)

机构地区：[1]深圳市人民医院,广东深圳518000

出　　处：《黑龙江医药》2017年第3期524-526,共3页Heilongjiang Medicine journal

摘　　要：目的:研究分析重症急性胰腺炎肺损伤患者中的PI3K/PKB信号转导通路临床表达及意义。方法:选取健康的成年大鼠30只作为主要的研究对象,随其进行随机分为三组,分别为A组、B组、C组,每组10只,应用胆胰管内递行注射法进行SAP模型的制作。在完成6小时制作之后,取出胰腺组织,完成各组指标的分析。结果:A组、B组、C组三组大鼠的相对指标均存在明显的差异,其中B组跟其他两组差异更为显著。其差异具有显著的统计学意义。A组、B组、C组三组大鼠的胰腺组织内TNF-、L-I蛋白变化以及PKB(碱的电离常数的负对数)变化差异存在明显的统计学意义。结论:重症急性胰腺炎肺损伤患者发病机制的主要原因可能是PI3K/PKB信号转导通路。Objective： To study the expression and significance of PI3K/PKB signal transduction pathway in patients with severe acute pancreatitis. Methods： 30 healthy adult rats were selected as the main research object, and were randomly divided into A group, B group and C group, with each group of 10 rats. The model of SAP was made. After 6 hours of production, remove the pancreatic tissue, complete the analysis of each index. Results： A group, B group, C group, the relative indicators of the three groups were significantly different, B group was significantly different from the other two groups. The difference was statistically significant. The changes of TNF-, L-I protein and PKB in pancreatic tissue of rats in group A, group B and group C were significantly different between the three groups. Conclusion： the main pathogenesis of severe acute panereatitis with lung injury may be the PI3K/PKB signal transduc- tion pathway.

关 键 词：重症急性胰腺炎肺损伤 PI3K/PKB 信号转导通路 临床表达 

分 类 号：R657.5[医药卫生—外科学]