儿童泌尿系感染大肠埃希菌的耐药性及抗菌药物分析  

Drug Resistance and Antimicrobial Agents of Escherichia Coli in Children with Urinary Tract Infection

作　　者：冯桂玲[1] 邱小梅[1] 林爱心[1] 刘东才[1] 黄洁红[1] 

机构地区：[1]中山市博爱医院,广东中山528400

出　　处：《黑龙江医药》2017年第5期992-994,共3页Heilongjiang Medicine journal

基　　金：广东省中山市科技计划项目(编号2014A1FC143)

摘　　要：目的:统计儿童泌尿系统感染疾病中大肠埃希菌的分离情况,分析大肠埃希菌的耐药性。方法:选择我院收治的泌尿系感染患者200例,进行病原菌的鉴定和分离,共分离161株大肠埃希菌,选取不同的抗菌药物进行耐药性实验;将感染大肠埃希菌的109例患者分为观察组和常规组,观察组根据病情资料给予泰能或丁胺卡那治疗,比较两种方案的治疗效果。结果:从耐药性结果分析,针对临床上常用的头孢类、氨苄西林、四环素类、左氧氟沙星等药物耐药性较强,而对舒巴坦、阿米卡星的耐药性较弱,尤其是泰能和丁胺卡那的药物敏感性最强;从治疗效果分析,丁胺卡那和泰能的治疗效果显著,与常规治疗相比,具有统计学意义。结论:在进行疾病治疗前鉴定病原菌的类型,充分了解细菌的耐药性,能够为临床用药提高依据,有利于保证治疗的合理性和安全性,而在大肠埃希菌所致的感染性疾病中,泰能和丁胺卡那均能够作为临床首选药物治疗。Objective： To investigate the isolation of Esehe- richia coli in children with urinary tract infection and to analyze the drug resistance of Escherichia. coll. Methods： our hospital patients with urinary tract infection in 200 eases, the identifica- tion and isolation of pathogenic fungi were isolated, 161 strains of Escherichia coli, selection of antimicrobial agents of different drug resistance; 109 eases of infection of Escherichia coil were divided into observation group and control group, the observa- tion group according to the disease information to imipenem or amikacin therapy, comparing the treatment efl^cls of the two kinds. Results： the results from the analysis of drug resistance, the clinical commonly used cephalosporins, ampicilliu, tetrae.y- cline and levofloxacin, drug resistance is strong, and sulbactam, Amikacin＇s resistance is weak, especially of imipenem and ami- kacin drug sensitivity is the highest; from the analysis of lhera- peutie effects of amikacin and imipenem treatment and com- pared with the conventional treatment, with statistical signifi- cance. Conclusion： the type of disease before treatment, patho-gen identification, fully understand the resistance of bacteria, can improve the basis for clinical medication, to ensure the ra- tionality and safety of the treatment, and the infectious diseases caused by Escherichia coli, that were able to used as the pre- ferred clinical drug treatment of imipenem and amikacin card.

关 键 词：儿童泌尿系统感染 大肠埃希菌 耐药性 抗菌药物 

分 类 号：R725.7[医药卫生—儿科]